ArticleJAMA network open2025
Orbitofrontal Gray-White Interface Injury and the Association of Soccer Heading With Verbal Learning.
Article in JAMA network open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk of Cognitive Decline in Professional Soccer Players after Repetitive Subconcussive Impacts: A Systematic Review and Meta-analysis.Neurologia medico-chirurgica · 2026Pooled it
- Cognitive and Behavioral Functioning in Female Former Soccer Players: Results from the Head Impact and Trauma Surveillance Study (HITSS).Brain sciences · 2026Article
- Brain MRI findings associated with soccer heading: a systematic review and meta-analysis.Neuroradiology · 2026Review
- Traumatic brain injury and neurological stealth syndromes.Frontiers in neuroscience · 2026Article
- Association Between Frontotemporal Atrophy and Cognitive Impairment in Patients with Schizophrenia Based on Computed Tomography Imaging.Neuropsychiatric disease and treatment · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Importance: Sport-related repetitive head impacts (RHIs) are linked to structural and functional brain changes and may be associated with risk for neurodegenerative disease. However, the locus of RHI-associated pathology that leads to adverse cognitive performance has yet to be characterized in vivo. Objective: To examine whether orbitofrontal gray matter-white matter interface (GWI) microstructure is associated with soccer RHI and whether it mediates the association of RHI with cognitive performance. Design, Setting, and Participants: This cross-sectional study, performed at Albert Einstein College of Medicine and Columbia University Irving Medical Center, included a population-based sample from the greater New York City area of amateur soccer players aged 18 to 55 years who played for at least 5 years, currently played at least 6 months per year, and were fluent in English. Exclusion criteria consisted of schizophrenia, bipolar disorder, current substance use disorder, any drug use within 30 days, and any contraindication to magnetic resonance imaging. Data were collected from November 11, 2013, to December 28, 2015, and analyses were performed from April 1 through December 4, 2024. Exposure: Soccer RHI exposure in the prior 12 months quantified via the HeadCount 12-month survey. Main Outcome and Measures: Slope of diffusion magnetic resonance imaging metrics (fractional anisotropy [FA], axial diffusivity, orientation dispersion index, and intracellular volume fraction) across the GWI was computed for each of 6 cerebral regions (cingulate, orbitofrontal, frontal, temporal, parietal, and occipital). The GWI slope association with RHI and with International Shopping List (ISL) immediate recall task performance, which is associated with RHI, were examined. Mediation analyses tested for the mechanistic role of GWI slope in the RHI and ISL association. Results: In 352 adult amateur soccer players aged 18 to 53 years (243 [69.0%] male; mean [SD] age, 25.6 [7.5] years), greater RHI exposure was associated with a less steep FA slope across the orbitofrontal GWI (estimate, 0.000001; P < .001). The orbitofrontal FA slope measure mediated the association of RHI with ISL performance (indirect effect estimate, -0.000064; P = .006). Conclusions and Relevance: In this cross-sectional study of soccer RHI, the orbitofrontal GWI emerged as a specific site of soccer RHI-related consequences, with FA slope suggesting that GWI microstructural disruption plays a mediating role in the association of greater RHI exposure with poorer verbal learning task performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.