ArticleScience progress
Identification and validation of mitochondrial ferroptosis and immune microenvironment-related hub biomarkers in liver cirrhosis by integrated bioinformatics analysis.
Article in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Decoding the spatiotemporal characteristics of ferroptosis: reshaping tumour therapeutic strategies.Experimental hematology & oncology · 2026Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundLiver cirrhosis represents a significant challenge to global public health. However, reliable biological markers for diagnosing liver cirrhosis are lacking in clinical practice.MethodsTranscriptome data from liver cirrhosis patients were acquired from the Gene Expression Omnibus database to identify coexpressed differentially expressed genes (DEGs). Mitochondria-related and ferroptosis-related genes were obtained from MitoCarta3.0 and FerrDB V2, respectively. Immune-related module genes were examined through Weighted Gene Co-Expression Network Analysis (WGCNA). By using WGCNA combined with machine learning methods, we identified immune-related biomarkers for liver cirrhosis. The immune cell infiltration was evaluated using CIBERSORTx, with core immune cell types further refined through LASSO regression and random forest. Hub biomarkers were validated using single-cell sequencing, with additional confirmation provided by histological staining and immunohistochemistry (IHC).ResultsThis study identified 2474 DEGs between liver cirrhosis and control groups. Intersection analysis with ferroptosis-related genes and mitochondria-related genes narrowed to 13 hub genes, from which machine learning selected 8 biomarkers. CIBERSORT and Wilcoxon tests revealed notable variations in the 12 immune cell types across the different groups. The WGCNA identified immune-related genes, with four immune-related biomarkers (
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Registered trials
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