Evidence map›Paper›PMID 40966295›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

ComFB, a widespread family of c-di-NMP receptor proteins.

Sherihan Samir, Abdalla A Elshereef, Vikram Alva, Jeanette Hahn, Frederik Eck, Louisa Celma, Eduardo S Lopes, Kai Thormann, David Dubnau, Michael Y Galperin and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Functional and structural insights into cyanobacterial COThe Plant journal : for cell and molecular biology · 2026
    Review
  3. Article
  4. Article
  5. c-di-GMP-Dependent Regulation of Motility bybioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Sherihan SamirInterfaculty Institute of Microbiology and Infection Medicine, Organismic Interactions Department, Cluster of Excellence "Controlling Microbes to Fight Infections - CMFI", Eberhard Karls University of Tübingen, Tübingen 72076, Germany.ORCID 0000-0003-4025-3005
Abdalla A ElshereefInterfaculty Institute of Microbiology and Infection Medicine, Organismic Interactions Department, Cluster of Excellence "Controlling Microbes to Fight Infections - CMFI", Eberhard Karls University of Tübingen, Tübingen 72076, Germany.
Vikram AlvaDepartment of Protein Evolution, Max Planck Institute for Biology, Tübingen 72076, Germany.ORCID 0000-0003-1188-473X
Jeanette HahnPublic Health Research Institute and Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, NJ 07103.ORCID 0000-0003-4230-1410
Frederik EckInstitute of Microbiology and Molecular Biology, Justus-Liebig-Universität Giessen, Gießen 35392, Germany.ORCID 0009-0001-0963-8436
Louisa CelmaPublic Health Research Institute and Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, NJ 07103.ORCID 0000-0002-6473-8915
Eduardo S LopesMicrobial Biochemistry Group, Institute of Phototrophic Microbiology, Heinrich-Heine University Düsseldorf, Düsseldorf 40225, Germany.ORCID 0000-0002-4554-447X
Kai ThormannInstitute of Microbiology and Molecular Biology, Justus-Liebig-Universität Giessen, Gießen 35392, Germany.ORCID 0000-0001-7292-4884
David DubnauPublic Health Research Institute and Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, NJ 07103.ORCID 0000-0001-9713-6120
Michael Y GalperinDivision of Intramural Research, National Library of Medicine, NIH, Bethesda, MD 20894.ORCID 0000-0002-2265-5572
Khaled A SelimInterfaculty Institute of Microbiology and Infection Medicine, Organismic Interactions Department, Cluster of Excellence "Controlling Microbes to Fight Infections - CMFI", Eberhard Karls University of Tübingen, Tübingen 72076, Germany.ORCID 0000-0002-2974-9483

Funding

Understanding the mechanism of genetic transformationR01GM057720 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI DAVID A DUBNAU, Matthew B Neiditch · 1998 to 2026
$15.4M
COMPARATIVE ANALYSIS OF COMPLETELY SEQUENCED GENOMESZ01LM000073 · NLM · NATIONAL LIBRARY OF MEDICINE · PI KOONIN, EUGENE V · 1996 to 2008
$1.2M
FINDING PROTEIN SEQUENCE MOTIFS--METHODS AND APPLICATIONSZ01LM000061 · NLM · NATIONAL LIBRARY OF MEDICINE · PI KOONIN, EUGENE V · 1994 to 2008
$645k
Improved protein-DNA models for translated sequence search with profile HMMsR15GM123487 · NIGMS · UNIVERSITY OF MONTANA · PI WHEELER, TRAVIS JOHN · 2017 to 2017
$426k
Deutsche Forschungsgemeinschaft (DFG) SE 3449/3-1Intramural NIH HHS Z01 LM000061Intramural NIH HHS Z01 LM000073NIGMS NIH HHS R01 GM057720NIGMS NIH HHS R15 GM123487
6 · The paper itself

Abstract

Cyclic dimeric-GMP (c-di-GMP) is a ubiquitous bacterial second messenger that regulates a variety of cellular processes, including motility, biofilm formation, secretion, cell cycle progression, and development, and also contributes to the virulence of many bacterial pathogens. While the genes encoding c-di-GMP cyclases and hydrolases are readily identifiable in microbial genomes, known c-di-GMP receptor domains are quite few, with only PilZ and MshEN broadly distributed across bacterial phyla. Recently, a new c-di-GMP receptor, named CdgR or ComFB, has been identified in cyanobacteria and shown to regulate cell size and natural competence. We demonstrated that CdgR proteins exhibit sequence and structural similarity to the

Indexed as

Bacterial ProteinsCyclic GMPBacillus subtilisPhylogenyShewanellaVibrio choleraeBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPbacterial motilityc-di-AMP signalingc-di-GMP signalingComFB superfamily

Identifiers

PMID40966295
PMCPMC12448109

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.