Evidence map›Paper›PMID 40967655›Full record

Trial reportBMJ open2025

Personalised exercise-rehabilitation for people with multiple long-term conditions (PERFORM): a randomised feasibility study.

Rachael A Evans, Sharon A Simpson, James R Manifield, Zahira Ahmed, Shaun Barber, Gwen Barwell, Sophie Eleanor Brown, Paulina Daw, Sarah G Dean, Patrick J Doherty and 18 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Rachael A EvansRespiratory Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0002-1667-868X
Sharon A SimpsonMRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0002-6219-1768
James R ManifieldRespiratory Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0002-5859-3772
Zahira AhmedRespiratory Sciences, University of Leicester, Leicester, UK.
Shaun BarberLeicester Clinical Trials Unit, University of Leicester, Leicester, UK.
Gwen BarwellLeicester Clinical Trials Unit, University of Leicester, Leicester, UK.
Sophie Eleanor BrownMRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0001-8622-5507
Paulina DawSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Sarah G DeanMedical School, University of Exeter, Exeter, UK.ORCID http://orcid.org/0000-0002-3682-5149
Patrick J DohertyHealth Sciences, University of York, York, UK.ORCID http://orcid.org/0000-0002-1887-0237
Heather FraserHealth Economics and Health Technology Assessment (HEHTA), University of Glasgow, Glasgow, UK.
Nikki GardinerUniversity Hospitals of Leicester NHS Trust, Leicester, UK.
Colin GreavesSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Tracy IbbotsonSchool of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Bhautesh JaniGeneral Practice and Primary Care, School of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Kate JollyDepartment of Applied Health Research, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-6224-2115
Frances MairGeneral Practice and Primary Care, School of Health and Wellbeing, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0001-9780-1135
Emma McIntoshHealth Economics and Health Technology Assessment (HEHTA), University of Glasgow, Glasgow, UK.
Dimitrios MegaritisDepartment of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, UK.
Daniel MillerUniversity of Leicester, Leicester, UK.
Paula OrmandySchool of Health and Society, University of Salford, Salford, UK.
Susan SmithSchool of Medicine, Trinity College Dublin, Dublin, Ireland.
Ioannis VogiatzisDepartment of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, UK.
Ghazala WaheedLeicester Clinical Trials Unit, University of Leicester, Leicester, UK.
Tom M WithersSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-5286-7189
Rod S TaylorMRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK.
Sally J SinghRespiratory Sciences, University of Leicester, Leicester, UK ss1119@leicester.ac.uk.
PERFORM Research Team

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveExisting exercise-based rehabilitation services, such as cardiac and pulmonary rehabilitation, are traditionally commissioned around single long-term conditions (LTCs) and therefore may not meet the complex needs of adults with multiple long-term conditions (MLTCs) or multimorbidity. The aim of this study was to assess the feasibility and acceptability of the newly developed personalised exercise-rehabilitation programme for people with multiple long-term conditions (PERFORM) and the trial methods.

designA parallel two-group mixed-methods feasibility randomised controlled trial (RCT) with embedded process and economic evaluation.

settingThree UK sites (two acute hospital settings, one community-based healthcare setting).

participants60 adults with MLTCs (defined as the presence of ≥2 LTCs) with at least one known to benefit from exercise therapy were randomised 2:1 to PERFORM intervention plus usual care (PERFORM group) or usual care alone (control group).

interventionThe intervention consisted of 8 weeks of supervised group-based exercise rehabilitation and structured self-care symptom-based support. PRIMARY AND SECONDARY OUTCOME MEASURES: Primary feasibility outcomes included: trial recruitment (percentage of a target of 60 participants recruited within 4.5 months), retention (percentage of participants with complete EuroQol data at 3 months) and intervention adherence (percentage of intervention group attending ≥60% sessions). Other feasibility measures included completion of outcome measures at baseline (pre-randomisation), 3 months post-randomisation (including patient-reported outcomes, exercise capacity and collection of health and social care resource use) and intervention fidelity.

resultsTarget recruitment (40 PERFORM group, 20 control group) was met within the timeframe. Participants were 57% women with a mean (SD) age of 62 (13) years, body mass index of 30.8 (8.0) kg/m

conclusionsOur findings support the feasibility and rationale for delivering the PERFORM comprehensive self-management and exercise-based rehabilitation intervention for people living with MLTCs and progression to a full multicentre RCT to formally assess clinical effectiveness and cost-effectiveness. TRIAL REGISTRATION NUMBER: ISRCTN68786622.

Indexed as

Exercise TherapyPrecision MedicineAgedChronic DiseaseFeasibility StudiesFemaleHumansMaleMiddle AgedMultimorbidityQuality of LifeUnited KingdomMultimorbidityREHABILITATION MEDICINESelf-Management

Identifiers

PMID40967655
PMCPMC12458827

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.