Evidence map›Paper›PMID 40968126›Full record

ArticleScientific reports2025

Spirostan and spirosol saponin derivatives from Solanum muricatum Aiton and their cytotoxic activities: insights into bioactive compounds and molecular mechanisms.

Fathy A Behery, Mohamed A M El Gendy, Mohamed A Zarka, Mubarak A Alzubaidi, Hesham A Abou-Zied, Gerhard Bringmann, Usama R Abdelmohsen, Abeer H Elmaidomy

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Phytochemical profiling ofRSC advances · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fathy A BeheryDepartment of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
Mohamed A M El GendyDrug Bioassay-Cell Culture Laboratory, Pharmacognosy Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, ElBohouth Street, (Former El Tahrir), P.O. 12622, Giza, Egypt.
Mohamed A ZarkaDepartment of Pharmacognosy, Department of College of Pharmacy, The Islamic University, Najaf, Iraq.
Mubarak A AlzubaidiDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Hesham A Abou-ZiedDepartment of Medicinal Chemistry, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt.
Gerhard BringmannInstitute of Organic Chemistry, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.
Usama R AbdelmohsenDeraya Center for Scientific Research, Deraya University, Minia, 61111, Egypt. usama.ramadan@mu.edu.eg.
Abeer H ElmaidomyDepartment of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt. Abeer011150@pharm.bsu.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Solanum muricatum Aiton (Family: Solanaceae), commonly known as pepino, is a traditionally used edible plant with reported medicinal properties, though its bioactive compounds remain largely unexplored. This study aimed to isolate cytotoxic constituents from its aerial parts and investigate their anticancer mechanisms. Two new spirostan-type saponins (1-2), and one known spirosol saponin (3) were identified via spectroscopic analysis. Among them, the plant extract and compound 3 showed significant cytotoxicity against A549 and HepG2 human cancer cell lines. Computational studies suggested PI3K-alpha as a key molecular target, with compound 3 showing strong binding affinity and stable interactions as confirmed by molecular dynamics simulations. These findings highlight the potential of S. muricatum saponins, particularly compound 3, as promising anticancer agents targeting PI3K-alpha.

Indexed as

Antineoplastic Agents, PhytogenicSaponinsSolanumSpirostansA549 CellsCell Line, TumorHep G2 CellsHumansMolecular Docking SimulationMolecular Dynamics SimulationPlant ExtractsAntineoplastic Agents, PhytogenicPlant ExtractsSaponinsSpirostansA549HepG2Molecular dockingSolanum muricatumSpirosol saponinsSpirostan

Identifiers

PMID40968126
PMCPMC12446479

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.