Evidence map›Paper›PMID 40968149›Full record

ArticleNPJ precision oncology2025

Diagnostic and prognostic roles of circulating EVs circ_PPAPDC1A in ICIs resistance in NSCLC.

Fang-Wen Zou, Yi-Fang Tang, Lei-Yi Zhang, Shun Xu, Shi-Ze Yang, Wen-Ya Li, Zheng-Hua Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fang-Wen ZouDepartment of Oncology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China.
Yi-Fang TangDepartment of Anesthesiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China.
Lei-Yi ZhangDepartment of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China.
Shun XuDepartment of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China.
Shi-Ze YangDepartment of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China.
Wen-Ya LiDepartment of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China.
Zheng-Hua LiuDepartment of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China. zhliu@cmu.eud.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ICIs resistance presents a significant challenge in clinical practice. Circulating extracellular vesicles circRNAs are promising biomarkers for cancer diagnosis and treatment. This study aimed to determine the oncogenic role of circulating extracellular vesicles circ_PPAPDC1A in ICIs resistance diagnosis and prognostic analysis of NSCLC. We used a co-culture system of NSCLC cells and T cells, and a mice xenograft assay, to evaluate the effect of circ_PPAPDC1A on anti-PD-1 antitumor activity. A multicenter cohort study of 40 patients analyzed the associations between extracellular vesicles circ_PPAPDC1A and ICIs resistance. In vitro, circ_PPAPDC1A reduced the sensitivity of NSCLC cells to ICIs by promoting proliferation and inhibiting apoptosis. In vivo, circ_PPAPDC1A promoted NSCLC progression and induced CD8

Identifiers

PMID40968149
PMCPMC12446451

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.