Evidence map›Paper›PMID 40968276›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Progression of the estimated glomerular filtration rate in asphyxiated neonates undergoing therapeutic hypothermia during the first 10 days of life.

Karel Allegaert, Julia Macente, Djalila Mekahli, John van den Anker, Pieter Annaert, Anne Smits

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Karel AllegaertClinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Herestraat 49, P.O. Box 611, Leuven, 3000, Belgium. karel.allegaert@kuleuven.be.ORCID http://orcid.org/0000-0001-9921-5105
Julia MacenteDrug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, 3000, Belgium.ORCID http://orcid.org/0000-0002-4452-5867
Djalila MekahliPKD Research Group, Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0003-0954-6088
John van den AnkerCenter for Translational Research, Children's National Hospital, Washington, DC, 20010, USA.ORCID http://orcid.org/0000-0003-0571-7492
Pieter AnnaertDrug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, 3000, Belgium.ORCID http://orcid.org/0000-0003-3525-7351
Anne SmitsDepartment of Development and Regeneration, KU Leuven, Leuven, 3000, Belgium.ORCID http://orcid.org/0000-0002-0710-6698

Funding

FWO Vlaanderen 18E2H24NFWO Vlaanderen G0D0520NOnderzoeksraad, KU Leuven CELSA 24/022
6 · The paper itself

Abstract

backgroundSerum creatinine (Scr) centile values were recently described in a cohort of 1136 (near)-term neonates that underwent therapeutic hypothermia (TH) because of moderate to severe hypoxic-ischemic encephalopathy. Recent methodological progress enables conversion of these Scr centiles to estimated glomerular filtration rate (eGFR) values.

methodsScr centiles in the TH dataset during the first 10 days of life were converted to eGFR values, using the Schwartz formula, with the Smeets k-value (0.31) and fixed body length (50 cm) to generate postnatal reference eGFR values, centiles, and an equation for median eGFRs. These findings were compared to published eGFR data in term controls.

resultsA polynomial function was estimated:

conclusionsBased on a pooled dataset in TH cases, we converted Scr centiles to eGFR centiles. Based on median values, this resulted in a polynomial function in TH cases, compared to healthy term neonates. This eGFR function enables precision pharmacotherapy for GFR-cleared drugs in this vulnerable population.

Indexed as

Acute Kidney InjuryAsphyxia NeonatorumGlomerular Filtration RateHypothermia, InducedHypoxia-Ischemia, BrainCreatinineFemaleHumansInfant, NewbornMaleReference ValuesCreatinineAcute kidney injuryAsphyxiaEstimated glomerular filtration rateNewbornTherapeutic hypothermia

Identifiers

PMID40968276
PMCPMC12686099

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.