SynthesisLasers in medical science2025
Full-Spectrum phototherapy in hair loss management: a systematic review of wavelength-dependent mechanisms, clinical efficacy, and future directions.
Synthesis in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- UV Protection Habits and Preferences in Patients With Distinct Cutaneous Immune-Mediated Inflammatory Diseases.Photodermatology, photoimmunology & photomedicine · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Alopecia is a complex condition with profound social and psychological implications, creating an urgent need for safe and effective therapeutic interventions. This review introduces a novel "Wavelength-Penetration Depth-Targeting Mechanism" model to clarify the multi-level regulatory effects of full-spectrum phototherapy (spanning from ultraviolet to mid-infrared wavelengths) on hair follicle regeneration. Unlike traditional treatments such as drugs and surgery, phototherapy provides non-invasive, wavelength-specific modulation of key pathways. Specifically, UVB/UVA selectively induce apoptosis of T cells, thereby restoring immune privilege in alopecia areata (AA). Red light activates mitochondrial cytochrome c oxidase, promoting dermal papilla cell proliferation and inhibiting the progression of androgenetic alopecia (AGA) and fibrosis in scarring alopecia. Short-wavelength near-infrared light enhances hair follicle angiogenesis and metabolic activity by penetrating deep tissues. Long-wavelength near-infrared and mid-infrared light can induce minimally invasive wound healing responses. Despite progress in clinical applications across different spectral bands, several challenges remain unresolved, including narrow therapeutic windows, variable patient responses, and limited tissue penetration. These factors collectively represent bottlenecks for the advancement of full-spectrum phototherapy. Future research directions encompass artificial intelligence-driven parameter optimization (e.g., dual-network deep learning for real-time hair follicle monitoring), collaborative strategies (e.g., dual-wavelength synergy and the use of optical clearing agents to enhance light transmission efficiency), and the integration of multi-dimensional efficacy evaluation. This review elucidates the significance and future development potential of phototherapy as a precise and non-invasive treatment modality, while also delineating feasible pathways for transitioning from mechanistic insights to clinical translation.
Indexed as
Identifiers
40968340What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.