ArticleMagnetic resonance in medicine2026
Optimization of pseudo-continuous arterial spin labeling for brain perfusion imaging in the intraoperative setting.
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Recent advances in arterial spin labeling MRI for imaging brain tumors.Magma (New York, N.Y.) · 2026Review
- Optimization of pseudo-continuous arterial spin labeling for brain perfusion imaging in the intraoperative setting.Magnetic resonance in medicine · 2026Article
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Authors and funding
12 authors.
Funding
Abstract
purposePseudo-continuous arterial spin labeling (PCASL) efficiency during intraoperative MRI is degraded due to large field inhomogeneities observed in some patients and lower arterial blood velocities induced by anesthesia. The purpose of this work was to maximize labeling efficiency during intraoperative MRI by optimizing PCASL parameters at 3 T.
methodsEffects of PCASL labeling pulse interval and gradient parameters on labeling efficiency were first investigated by numerical simulations based on Bloch equations. PCASL parameters were modified accordingly, considering hardware constraints, and evaluated experimentally. An experiment in healthy volunteers compared three labeling pulse intervals. In intraoperative brain tumor patients, different configurations were tested in two experiments: different labeling pulse intervals in patient experiment 1, and different labeling pulse interval and gradient average (
resultsNumerical simulations showed that shortening the labeling pulse interval improved robustness of PCASL to off-resonance effects and that raising the
conclusionShortening the labeling pulse interval and increasing the gradient average improves PCASL efficiency in the intraoperative setting.
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