ArticleInternational journal of surgery (London, England)2026
Association between circulating selenium levels and arterial stiffness: a nationwide cross-sectional study.
Article in International journal of surgery (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Association of physical activity with arterial stiffness: the mediating role of the visceral fat metabolism score.Archives of endocrinology and metabolism · 2026Article
- Dietary Mineral Intake and Vascular Health in Patients with Long COVID-19: The BioICOPER Study.Nutrients · 2026Article
- Letter to the editor "association between circulating selenium levels and arterial stiffness: a nationwide cross-sectional study".International journal of surgery (London, England) · 2025Article
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6 authors.
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Abstract
backgroundAtherosclerotic cardiovascular disease (ASCVD) is the leading cause of death worldwide. Arterial stiffness is an important pathological characteristic of ASCVD. Selenium (Se) may have a notable effect of arterial stiffness. However, the relationship between circulating Se (CSe) levels and arterial stiffness remains unclear.
methodsA total of 11 937 participants from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018 were enrolled. The relationship between CSe levels, estimated pulse wave velocity (ePWV), and the atherogenic index of plasma (AIP) was evaluated using univariate and multivariate linear regression, dose-response, and mediation analyses.
resultsA linear relationship between the CSe index and high AIP ( P for nonlinearity = 0.1) and a U-shaped relationship between the CSe index and high ePWV were found ( P for nonlinearity < 0.001). In fully adjusted models, the relationship between CSe and high AIP was positive (OR = 1.48, 95% CI: 1.20, 1.82; P = 0.001). An inflection point was found in the relationship between the CSe index and high ePWV. CSe levels of < 2.99 μmol/L were negatively related to high ePWV (OR = 0.71; 95% CI: 0.59, 0.86; P < 0.001). In contrast, CSe levels of ≥ 2.99 μmol/L were positively related to high ePWV (OR = 2.66; 95% CI: 1.66, 4.25; P < 0.001). Furthermore, the indirect effect mediated by the sex of CSe on high AIP was prominent (indirect effect = 0.006; 95% CI: 0.003, 0.008; percent mediation = 26.49%) in the fully adjusted models.
conclusionsOur findings suggests a significant relationship between CSe levels and arterial stiffness, the mechanism behind which should be further explored.
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