Evidence map›Paper›PMID 40968783›Full record

ReviewInternational journal of cancer2026

The role of cytokines in ovarian cancer drug resistance.

Lu Wang, Yunxia Zang, Rebeka Dejenie, Junyuan Bing, Shixia Dong, Yanfei Zhang, Yi Zhu, Jingjing Li

Abstract readReview
In one paragraph

Review in International journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The role of cytokines in ovarian cancer drug resistance.International journal of cancer · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lu WangSchool of Clinical Medicine, Shandong Second Medical University, Weifang, China.
Yunxia ZangSchool of Clinical Medicine, Shandong Second Medical University, Weifang, China.
Rebeka DejenieUniversity of Chicago Medical Center, Chicago, Illinois, USA.
Junyuan BingSchool of Clinical Medicine, Shandong Second Medical University, Weifang, China.
Shixia DongJinming Yu Academician Workstation of Oncology, Affiliated Hospital of Shandong Second Medical University, Weifang, China.
Yanfei ZhangJinming Yu Academician Workstation of Oncology, Affiliated Hospital of Shandong Second Medical University, Weifang, China.
Yi ZhuUniversity of Chicago Medical Center, Chicago, Illinois, USA.
Jingjing LiJinming Yu Academician Workstation of Oncology, Affiliated Hospital of Shandong Second Medical University, Weifang, China.

Funding

National Natural Science Foundation of China 82104289Qilu Biancang Traditional Chinese Medicine Talent Cultivation ProjectScience and Technology Project jointly established by the Science and Technology Department of the State Administration of Traditional Chinese Medicine GZY-KJS-SD-2023-079Shandong Provincial Health Commission M-2022053Shandong Provincial Key Medical and Health Discipline of Oncology (Affiliated Hospital of Shandong Second Medical University)Shandong Provincial Medical Association Young Talent Promotion Project 2023_GJ_0039Weifang Key Laboratory of Biomimetic DiagnosticsWeifang Science and Technology Bureau Plan Project 2021YX081Yuandu Scholar Grant of Weifang City to LJJ, Science and Technology Innovation Plan from Weifang Medical University 041004
6 · The paper itself

Abstract

Ovarian cancer is the leading cause of death among women diagnosed with female reproductive system cancers. While significant advances have been made in treating various types of cancer, progress in ovarian cancer treatment over the past 20 years has been minimal, and the treatment course of ovarian cancer is not linear. Although many patients initially respond to treatment and may experience tumor regression, 80% of patients relapse after one or multiple chemotherapy sessions. Cytokines play a crucial role in driving tumor progression, relapse, and drug resistance in ovarian cancer. The knowledge of ovarian cancer drug resistance and the function of cytokines in the development of tumor resistance is currently the subject of numerous relevant studies; meanwhile, the specific molecular pathways are being unearthed. Herein, we summarize the recent advancements in cytokine-associated ovarian cancer drug resistance. In addition, we also present the cytokine targeting drugs in ameliorating ovarian cancer drug resistance. As multi-effect factors, cytokines can induce multiple pathways to promote tumor progression and overcome extremely complex and heterogeneous living environments. From the perspective of various paths of cytokine function, the emergence of multi-target drugs might be more promising for conquering ovarian cancer chemotherapy drug resistance.

Indexed as

CytokinesDrug Resistance, NeoplasmOvarian NeoplasmsAnimalsAntineoplastic AgentsFemaleHumansTumor MicroenvironmentAntineoplastic AgentsCytokinescytokinedrug resistanceIL6ovarian cancertumor microenvironment

Identifiers

PMID40968783
PMCPMC12712370

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.