Evidence map›Paper›PMID 40969108›Full record

ArticleNMR in biomedicine2025

Evaluating a Cellular Microstructure Model Within Apoptotic Cell Death via Diffusion Magnetic Resonance and Long Diffusion Times.

Daniel Djayakarsana, Gregory J Czarnota, Colleen Bailey, Greg J Stanisz

Abstract read
In one paragraph

Article in NMR in biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel DjayakarsanaPhysical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Gregory J CzarnotaPhysical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Colleen BaileyPhysical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Greg J StaniszPhysical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.

Funding

Canada Research Chairs CRC-2019-00384CIHR PJT180272Natural Sciences and Engineering Research Council of Canada
6 · The paper itself

Abstract

The growing trend for personalized cancer treatment needs a complementary system to detect treatment response more rapidly and robustly. Inducing apoptosis is still a common treatment target as the immune system can clear the apoptotic cancer cells. Many studies have demonstrated the potential of diffusion-based MRI techniques for detecting apoptotic changes in tumors by correlating the changes of cellularity. Here we used diffusion data with long diffusion times to elucidate water exchange rates in acute myeloid leukemia cells (AML) which were acquired using stimulated echo acquisition mode (STEAM) in diffusion imaging. The two-pool exchange model was fitted where the key parameters of interest were the intracellular fraction,

Indexed as

ApoptosisDiffusion Magnetic Resonance ImagingModels, BiologicalCell Line, TumorCisplatinDiffusionHumansLeukemia, Myeloid, AcuteCisplatin

Identifiers

PMID40969108
PMCPMC12447260

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.