Evidence map›Paper›PMID 40969148›Full record

ArticlePhysiological reports2025

Adipocyte-specific ET

Bridget D Konadu, Osvaldo Rivera-Gonzales, Natalie A Wilson, Madilyn Lewis, Hayley A Murphy, Megumi F Mills, Laura E Coats, Joshua K Michael, Jennifer R Stapel, Joshua S Speed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Adipocyte-specific ETPhysiological reports · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bridget D KonaduDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Osvaldo Rivera-GonzalesDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Natalie A WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Madilyn LewisDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Hayley A MurphyDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Megumi F MillsDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Laura E CoatsDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Joshua K MichaelDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Jennifer R StapelDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Joshua S SpeedDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.ORCID https://orcid.org/0000-0002-0131-5253

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
Hypertension and Cardiorenal Research Training ProgramT32HL105324 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Joey P. Granger · 2010 to 2026
$7.8M
Pilot Projects ProgramP30GM149404 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI John E Hall · 2023 to 2026
$6.3M
Endothelin-1 in Obesity and Insulin ResistanceR01DK124327 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI SPEED, JOSHUA S · 2021 to 2025
$2.2M
NHLBI NIH HHS T32 HL105324NIDDK NIH HHS R01 DK124327NIGMS NIH HHS P30 GM149404NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

In rodent models of diet-induced obesity, a metabolic syndrome-like phenotype develops that is more pronounced in males compared to females. Our lab reported that endothelin-1 (ET-1) is increased in visceral adipose of high-fat diet-fed (HFD) mice where it inhibits adiponectin production through activation of the ET-1 type B receptor (ET

Indexed as

AdipocytesDiet, High-FatDyslipidemiasInsulin ResistanceObesityReceptor, Endothelin BAnimalsEndothelin-1FemaleMaleMiceMice, Inbred C57BLEDNRB protein, mouseEndothelin-1Receptor, Endothelin Badiposeendothelininsulin resistanceobesitysex differences

Identifiers

PMID40969148
PMCPMC12446993

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.