ArticleFrontiers in neurology2025
Evaluation of degree centrality and neurological outcomes in patients with herpes simplex encephalitis.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Altered amplitude of low-frequency fluctuations in herpes simplex encephalitis: a resting-state fMRI study and associations with anxiety.Brain imaging and behavior · 2026Article
- Decoding Post-Stroke Cognitive Impairment After Acute Basal Ganglia Infarction: The Synergistic Role of Functional Segregation and Integration in an SVM fMRI Framework.CNS neuroscience & therapeutics · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
Objective: This study aimed to investigate the association between changes in cerebral degree centrality (DC) and clinical outcomes in patients with herpes simplex encephalitis (HSE). Methods: All participants underwent functional magnetic resonance imaging (fMRI), and DC analysis was used to identify voxels that showed changes in whole-brain functional connectivity with other voxels. DC was evaluated using the fMRI graph method, and comparisons between HSE patients and controls were performed. The National Institutes of Health Stroke Scale (NIHSS), the Glasgow Coma Scale (GCS), and the modified Rankin Scale (mRS) were assessed for all HSE patients. Results: A total of 70 HSE patients and 76 controls were included in our data analysis. In the HSE group, DC values were increased in the right thalamus, the left lingual gyrus, and the right hippocampus, while they were decreased in the left insula (all Conclusion: Cerebral intrinsic connectivity changes as assessed by DC in HSE were associated with neurological deficits (as assessed by the NIHSS score), level of consciousness (as assessed by the GCS score), and functional disability. Our findings provide novel insights into the neural mechanisms underlying HSE-related neurological deficits and inform the development of targeted therapeutic interventions.
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