ArticleFrontiers in neurology2025
Hyperbaric oxygen therapy improves post-concussion symptoms in adults with childhood traumatic brain injury: a retrospective cohort study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Post-concussion syndrome (PCS) following childhood traumatic brain injury (TBI) can result in persistent cognitive impairments that extend into adulthood, yet it remains significantly underdiagnosed and undertreated. This study evaluated the effects of hyperbaric oxygen therapy (HBOT) on chronic neurocognitive symptoms in adults with PCS stemming from pediatric TBI. We conducted a retrospective analysis of patients treated with HBOT at the "Sagol Center for Hyperbaric Medicine and Research" between 2017 and 2024. Inclusion criteria included TBI before age 17, HBOT initiation after age 20, and the availability of computerized cognitive assessments before and after treatment. All participants received at least 40 sessions of HBOT, consisting of 90 min of 100% oxygen at 2 ATA with air breaks. Twenty-six adults (mean age 31.7 ± 8.6 years) who sustained TBI in childhood (mean age at injury 7.7 ± 5.8 years) met inclusion criteria. Following HBOT, statistically significant improvements were observed in all cognitive domains except for motor skills (global cognition, memory, executive function, attention and information processing speed; all adjusted
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