SynthesisF1000Research2025
THE PROTECTIVE ROLE OF FLAVONOIDS IN AMNESIA -SYSTEMATIC REVIEW.
Synthesis in F1000Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The multi-pathway treatment of flavonoids as natural compounds in neurological diseases: achievements, limitations, and prospects.Frontiers in neuroscience · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Amnesia, a debilitating memory disorder, often arises from neurodegenerative diseases, oxidative stress, and synaptic dysfunction. Current therapies offer limited efficacy and are associated with adverse effects, prompting exploration of safer neuroprotective agents. Flavonoids, abundant in fruits, vegetables, and medicinal plants, have emerged as promising candidates due to their antioxidant, anti-inflammatory, and neurotrophic properties. Objective: This systematic review critically evaluated experimental evidence on the protective role of flavonoids in amnesia, highlighting their mechanisms of action, therapeutic outcomes, and translational potential. Methods: A comprehensive literature search was conducted using structured search strategies across the Web of Science, Scopus, and PubMed databases. Studies published between 2010 and 2024 were screened according to PRISMA 2020 guidelines. Only original experimental research investigating flavonoid interventions in animal models of amnesia was included. Results: Out of 593 retrieved articles, 25 studies met the inclusion criteria. Behavioral assessments predominantly employed the Morris Water Maze, Novel Object Recognition Test, and Y-Maze to evaluate cognitive performance. Flavonoid interventions consistently improved memory functions, reduced oxidative stress markers (MDA), enhanced antioxidant defenses (GSH, SOD, CAT), and modulated neuroprotective gene expressions (BDNF, CREB1, Nrf2). Both crude plant extracts and isolated flavonoids, administered primarily via oral routes, demonstrated robust efficacy. Animal models included Swiss albino mice, Wistar rats, and zebrafish. Conclusions: Flavonoids exhibit multi-targeted neuroprotection against amnesia by enhancing synaptic plasticity, combating oxidative damage, and modulating apoptotic pathways. These findings support advancing flavonoids toward clinical applications for cognitive disorders, warranting further translational studies and optimized formulations.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.