Evidence map›Paper›PMID 40969394›Full record

ReviewMaterials today. Bio2025

Precise modulation of redox reactions: A novel multifunctional theranostic platform based on 2D nanozymes.

Wencheng Wu, Xianwei Yang, Deyu Zhang, Hanxiao Cui, Xinyue Wang, Bangguo Zhou, Yuyan Zhou, Haojie Huang, Zhangqi Lai

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wencheng WuThe Third School of Clinical Medicine (School of Rehabilitation Medicine), Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Xianwei YangDepartment of Thyroid Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Deyu ZhangDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, China.
Hanxiao CuiDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, China.
Xinyue WangDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, China.
Bangguo ZhouDepartment of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
Yuyan ZhouDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, China.
Haojie HuangDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, China.
Zhangqi LaiThe Third School of Clinical Medicine (School of Rehabilitation Medicine), Zhejiang Chinese Medical University, Hangzhou, 310053, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biological enzymes, with their high catalytic activity, strong specificity, and biocompatibility, hold significant application value in the biomedical field. However, their practical use is limited by high costs, poor environmental stability, and difficulties in large-scale production. In recent years, two-dimensional (2D) nanomaterials, with their high surface area, tunable enzyme-like catalytic activities (such as oxidase/peroxidase/catalase-mimicking properties), and unique photothermal/photodynamic effects, have provided new strategies for disease diagnosis and treatment. In this review, we first elucidate the bidirectional regulatory capacity of 2D nanozymes for redox reactions. We then classify and introduce the structural characteristics and catalytic mechanisms of various 2D nanozyme platforms, including carbon-based materials, black phosphorus, layered double hydroxides, transition metal oxides, metal-organic frameworks, MXenes, and other emerging nanomaterials. Finally, we summarize the latest research progress of 2D nanozymes in applications such as biosensors, cardiovascular diseases, bacterial infections, diabetic wounds, inflammatory bowel disease, arthritis, ischemic stroke, and cancer, highlighting their multifunctional theranostic effects. This review aims to provide theoretical references for the development of highly efficient and stable nanozyme materials and to promote the interdisciplinary development of catalytic medicine and nanotechnology.

Indexed as

Biological enzymesCatalytic activityNanosheetsNanotechnologyNanozymesRedox regulationROS regulationTwo-dimensional (2D) nanomaterials

Identifiers

PMID40969394
PMCPMC12441727

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.