ArticleFrontiers in microbiology2025
Cadmium's silent sabotage: unveiling its impact on antibiotic efficacy.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Despite advancements in non-antibiotic therapies, antibiotics continue to be the cornerstone of bacterial infection management. However, the overuse of antibiotics has led to an increase in clinical failures, a situation worsened by the phenomenon of bacterial antibiotic tolerance, which remains less understood than genetic resistance. Environmental stressors, including heavy metals like cadmium, have been associated with heightened susceptibility to infections, yet their influence on antibiotic efficacy has not been thoroughly investigated. In this study, we demonstrate that chronic exposure to cadmium diminishes the effectiveness of antibiotics in systemic infections, as evidenced by a mouse model. From a mechanistic perspective, alterations in the composition of endogenous metabolites due to changes in gut microbiota, notably the diminished production of DL-mevalonolactone, impede bacterial clearance. This is because DL-mevalonolactone plays a crucial role in facilitating the eradication of antibiotic-tolerant bacteria by activating their metabolic processes. Our findings underscore the detrimental impact of cadmium on antibiotic treatment, emphasizing the health risks associated with cadmium exposure.
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