ArticleFrontiers in nutrition2025
An examination into the effects of tocotrienols (TheraPrimE® rice) on cognitive abilities and sleep in healthy adults: a randomised, double-blind, placebo-controlled trial.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Comparative neuroprotective and antioxidant roles of vitamin E isoforms: a review.Journal of clinical biochemistry and nutrition · 2026Review
- An Examination into the Anti-stress and Anti-fatigue Effects of an Ashwagandha Extract (Ashwa.30™) in Stressed Adults: A Randomised, Double-Blind, Placebo-controlled Trial.Advances in therapy · 2026Article
- Targeting the Sleep-Glymphatic-Vascular Continuum in Cerebral Small Vessel Disease: A Nutritional Perspective on Neuroprotective Potential of Tocotrienols (T3).Life (Basel, Switzerland) · 2026Review
- The effect of a topical curcumin formulation (VAS-101) on knee pain in adults with knee osteoarthritis: a randomised, double-blind, placebo-controlled study.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/objectives: Tocotrienols are a form of vitamin E that may have neuroprotective effects. However, there have been no studies examining its effects on cognitive function when delivered as a stand-alone intervention. The purpose of this two-arm, 12-week, randomised, double-blind, placebo-controlled trial was to examine the effects of supplementation with tocotrienols derived from rice bran (TheraPrimE® rice) on memory and sleep in adults with subjective memory complaints. Methods: Ninety-one adults aged 40-80 were supplemented with a placebo or 100 mg of tocotrienols daily. Outcome measures included the Test of Memory and Learning (version 2), and self-report questionnaires assessing executive function and sleep quality. Moreover, changes in blood markers associated with inflammation, oxidative stress, and neurotropic activity were examined. Results: Compared to the placebo, tocotrienol supplementation was associated with greater improvements in general memory ( Conclusion: This is the first controlled study demonstrating the cognitive-enhancing and sleep-promoting effects of stand-alone supplementation with tocotrienols. However, future research is required to substantiate this study's results and examine the potential mechanisms of action. Clinical trial registration: https://www.anzctr.org.au/ACTRN12624000351516.aspx, Identifier ACTRN12624000351516.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.