Evidence map›Paper›PMID 40969758›Full record

Observational studyFrontiers in immunology2025

Changes in monocyte subsets are associated with an increased risk of AAA and are surrogate markers for AAA morphology in patients with late-stage disease.

Bianca Hamann, Anna Klimova, Marvin Kapalla, David M Poitz, Albert Busch, Henning Morawietz, Christian Reeps, Anja Hofmann

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bianca HamannDivision of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surger, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
Anna KlimovaInstitute for Medical Informatics and Biometry, Faculty of Medicine, TUD Dresden University of Technology, Dresden, Germany.
Marvin KapallaDivision of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surger, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
David M PoitzInstitute for Clinical Chemistry and Laboratory Medicine; University Hospital and Medical Faculty Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
Albert BuschDivision of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surger, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
Henning MorawietzDivision of Vascular Endothelium and Microcirculation, Department of Medicine III, University Hospital and Medical Faculty Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
Christian ReepsDivision of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surger, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
Anja HofmannDivision of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surger, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Monocytes play a role in the pathology of abdominal aortic aneurysm (AAA) and can display immunophenotypic heterogeneity. Alterations in monocyte subsets are associated with cardiovascular risk, but their profile in AAA is poorly understood. Aim: We aimed to comprehensively define associations of monocyte phenotypes with AAA risk and AAA morphology. Methods: Monocyte subsets (CD14++CD16-, CD14++/CD16+, and CD14+/CD16++) were analyzed in an observational study in patients with AAA (n = 33) and varicose veins (n = 33) using flow cytometry. Results: Classical monocytes were 3% lower ( Conclusion: The present study revealed age- and sex-independent shifts in monocytes, all of which were associated with the risk of AAA disease. Non-classical monocytes were inversely correlated with AAA diameter and volume and thus may be surrogate markers for AAA morphology.

Indexed as

Aortic Aneurysm, AbdominalMonocytesAgedBiomarkersFemaleHumansImmunophenotypingLipopolysaccharide ReceptorsMaleMiddle AgedReceptors, IgGRisk FactorsBiomarkersLipopolysaccharide ReceptorsReceptors, IgGAAAbiomarkercardiovascularmonocyte subsetssurrogate marker

Identifiers

PMID40969758
PMCPMC12442832

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.