ArticleFrontiers in immunology2025
Zinc alleviates stroke development through autophagy-mediated modulation of immune microenvironment.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Stroke is a leading cause of death and long-term disability worldwide and is increasingly recognized as a neuroinflammatory, immune-mediated disease. Acute ischemia triggers robust activation and infiltration of innate immune cells, exacerbating neuronal injury. Zinc is an essential micronutrient with known immunomodulatory and autophagy-regulating roles, but its impact on stroke-driven neuroinflammation remains unclear. We aimed to investigate whether zinc protects against ischemic brain injury by modulating autophagy and the immune microenvironment. Methods: Genome-wide association (GWAS) and NHANES cohort analyses were performed to assess the association between zinc intake levels and stroke risk. Pathway enrichment analysis, PPI network construction, and diagnostic modeling were undertaken to identify ZIARs (zinc-responsive immuno-autophagic regulators). Immune infiltration analysis was used to assess immune cell infiltration levels in stroke. Cell-based ischemia-reperfusion experiments were conducted to evaluate zinc's effects on autophagy and neuronal cell injury. Results: Higher zinc levels were associated with lower stroke prevalence, as supported by GWAS results (OR ~0.141) and NHANES findings (adjusted OR ~0.96). Zinc-associated genes were predominantly enriched in autophagy and inflammatory signaling pathways, including PI3K-Akt and NF-κB. The diagnostic model identified ZIARs whose expression was closely linked to immune cell composition, particularly neutrophil infiltration, in stroke. Conclusion: Zinc confers neuroprotection in ischemic stroke by restoring autophagic flux and suppressing excessive innate inflammation through regulation of ZIARs. These findings underscore zinc's neuroprotective role via immune-autophagy crosstalk and position it as a potential strategy for stroke prevention and intervention.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.