ArticleACS pharmacology & translational science2025
Hyperfiltration and Elevated Fractional Excretion of Magnesium in Children with Cystic Fibrosis.
Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Several critical knowledge gaps exist in understanding and managing renal function in pediatric patients with cystic fibrosis (CF). A limited amount of data demonstrates hyperfiltration in CF, yet it is unknown how these changes in relation to intravenous (IV) aminoglycosides and evolves into chronic kidney disease in CF. Similarly, there is limited information on the fractional excretion of magnesium (FEMg) in relation to acute kidney injury induced by IV aminoglycosides. The PIANO-CF trial was a single-center study conducted at a pediatric hospital in Australia, looking at young children with CF who were admitted for IV aminoglycoside therapy. In relation to IV aminoglycoside therapy, the study evaluated the estimated glomerular filtration rate, serum magnesium, FEMg, and urine creatinine (UCr). For children with CF admitted for IV aminoglycosides, estimated glomerular filtration rate indicated hyperfiltration in 87% at baseline and 81% post-IV aminoglycosides. A significant increase in FEMg was observed with treatment, with a mean increase of 2.6% (
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