Evidence map›Paper›PMID 40969884›Full record

ArticleACS pharmacology & translational science2025

Highly Potent and Subtype-Selective Sperm-Specific Potassium Channel SLO3 Inhibitors Display High Tissue Exposure in the Murine Female Reproductive Tract.

Kayla J Temple, Ping Li, Hallie G McKinnie, Analisa Thompson Gray, Jeanette L Bertron, Anna E Ringuette, Pedro de Andrade Horn, Maximilian D Lyon, Shweta Bhagwat, Leila Asadi and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Kayla J TempleWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.ORCID https://orcid.org/0000-0001-5290-574X
Ping LiDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Hallie G McKinnieWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Analisa Thompson GrayWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Jeanette L BertronWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Anna E RinguetteWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Pedro de Andrade HornWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Maximilian D LyonDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Shweta BhagwatDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Leila AsadiDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Sophia LiDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Roman M LazarenkoDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Ronald McCarthyDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Sichen ChangWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Jeremy A TurkettWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Valerie KramlingerWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Katherine J WatsonWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Irene A Zagol-IkapitteWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Jerod S DentonDepartment of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
Celia M SantiDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Carrie K JonesWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Craig W LindsleyWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Olivier BoutaudWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.

Funding

Developing modulators of the sperm-specific potassium channel SLO3 for contraceptionR33HD099742 · NICHD · WASHINGTON UNIVERSITY · PI DENTON, JEROD S., SANTI, CELIA M · 2021 to 2023
$2.1M
Developing modulators of the sperm-specific potassium channel SLO3 for contraceptionR61HD099742 · NICHD · WASHINGTON UNIVERSITY · PI DENTON, JEROD S., SANTI, CELIA M · 2019 to 2020
$836k
NICHD NIH HHS R33 HD099742NICHD NIH HHS R61 HD099742
6 · The paper itself

Abstract

To date, the study of drug exposure and distribution throughout the female reproductive tract has often been overlooked and neglected. Herein, we report the first highly potent and subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitors as a new modality of contraceptives. After extensive

Indexed as

contraceptiondrug distributiondrug metabolismexposurepharmacokineticsSLO3 inhibitors

Identifiers

PMID40969884
PMCPMC12441834

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.