Evidence mapPaperPMID 40969893Full record

ArticleACS pharmacology & translational science2025

Quinolylnitrone 23 Protects from Auditory Cell Oxidative Injury and Noise-Induced Hearing Loss.

Silvia Murillo-Cuesta, Julio Contreras, Mourad Chioua, Carmen García-Montoya, Lourdes Rodríguez-de la Rosa, Inés Méndez-Grande, Dorota G Piotrowska, Iwona E Głowacka, Isabel Varela-Nieto, José Marco-Contelles

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Silvia Murillo-CuestaInstitute for Biomedical Research "Sols-Morreale", Spanish National Research Council-Autonomous University of Madrid (CSIC-UAM), 28029 Madrid, Spain.ORCID https://orcid.org/0000-0002-8706-4327
Julio ContrerasInstitute for Biomedical Research "Sols-Morreale", Spanish National Research Council-Autonomous University of Madrid (CSIC-UAM), 28029 Madrid, Spain.ORCID https://orcid.org/0000-0002-2145-4090
Mourad ChiouaLaboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Madrid 29006, Spain.
Carmen García-MontoyaInstitute for Biomedical Research "Sols-Morreale", Spanish National Research Council-Autonomous University of Madrid (CSIC-UAM), 28029 Madrid, Spain.ORCID https://orcid.org/0000-0001-6424-0538
Lourdes Rodríguez-de la RosaInstitute for Biomedical Research "Sols-Morreale", Spanish National Research Council-Autonomous University of Madrid (CSIC-UAM), 28029 Madrid, Spain.
Inés Méndez-GrandeInstitute for Biomedical Research "Sols-Morreale", Spanish National Research Council-Autonomous University of Madrid (CSIC-UAM), 28029 Madrid, Spain.ORCID https://orcid.org/0009-0004-2152-3174
Dorota G PiotrowskaBioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
Iwona E GłowackaBioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
Isabel Varela-NietoInstitute for Biomedical Research "Sols-Morreale", Spanish National Research Council-Autonomous University of Madrid (CSIC-UAM), 28029 Madrid, Spain.ORCID https://orcid.org/0000-0003-3077-0500
José Marco-ContellesCentre for Biomedical Network Research on Rare Diseases (CIBERER), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress is a key pathogenic mechanism in noise-induced hearing loss, occurring when the production of free radicals in the cochlea overwhelms its antioxidant defenses. Thus, antioxidant molecules, including

Indexed as

antioxidantscochlear injuryHEI-OC1 auditory cellsNlrp3Nrf2oxidation-mediated hearing loss

Identifiers

PMID40969893
PMCPMC12441856

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.