Evidence map›Paper›PMID 40969903›Full record

ArticleACS pharmacology & translational science2025

P2Y

Asmita Pramanik, Zhiwei Wen, Matteo Pavan, Siva Hariprasad Kurma, Tadeusz Karcz, Sarah A Lewicki, Naili Liu, Tamar Demby, Oksana Gavrilova, Paola Oliva and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Asmita PramanikMolecular Recognition Section, Laboratory of Bioorganic Chemistry, and, National Institutes of Health, Bethesda, Maryland 20892, United States.
Zhiwei WenMolecular Recognition Section, Laboratory of Bioorganic Chemistry, and, National Institutes of Health, Bethesda, Maryland 20892, United States.
Matteo PavanMolecular Recognition Section, Laboratory of Bioorganic Chemistry, and, National Institutes of Health, Bethesda, Maryland 20892, United States.
Siva Hariprasad KurmaMolecular Recognition Section, Laboratory of Bioorganic Chemistry, and, National Institutes of Health, Bethesda, Maryland 20892, United States.
Tadeusz KarczFaculty of Pharmacy, Jagiellonian University Medical College, Kraków 30-688, Poland.
Sarah A LewickiMolecular Recognition Section, Laboratory of Bioorganic Chemistry, and, National Institutes of Health, Bethesda, Maryland 20892, United States.
Naili LiuMouse Metabolic Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.
Tamar DembyMouse Metabolic Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.
Oksana GavrilovaMouse Metabolic Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.
Paola OlivaMolecular Recognition Section, Laboratory of Bioorganic Chemistry, and, National Institutes of Health, Bethesda, Maryland 20892, United States.
Katharina S ErlitzMolecular Recognition Section, Laboratory of Bioorganic Chemistry, and, National Institutes of Health, Bethesda, Maryland 20892, United States.
Anna JunkerDepartment of Preclinical Imaging and Radiopharmacy, University of Tübingen, Tübingen 72076, Germany.
Young-Hwan JungMolecular Recognition Section, Laboratory of Bioorganic Chemistry, and, National Institutes of Health, Bethesda, Maryland 20892, United States.
Zhoumou ChenDepartment of Pharmacology and Physiology and the Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University School of Medicine, 1402 South Grand Blvd., St. Louis, Missouri 63104, United States.
Daniela SalveminiDepartment of Pharmacology and Physiology and the Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University School of Medicine, 1402 South Grand Blvd., St. Louis, Missouri 63104, United States.
Joseph KousourosDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene Street, Baltimore, Maryland 21201, United States.
Zhan-Guo GaoMolecular Recognition Section, Laboratory of Bioorganic Chemistry, and, National Institutes of Health, Bethesda, Maryland 20892, United States.
Jonathan F FayDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene Street, Baltimore, Maryland 21201, United States.
Kenneth A JacobsonMolecular Recognition Section, Laboratory of Bioorganic Chemistry, and, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID https://orcid.org/0000-0001-8104-1493

Funding

Development Of P2Y Receptor LigandsZIADK031116 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$8.9M
Computer Modeling of G Protein-Coupled ReceptorsZIADK031126 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$6.6M
Intramural NIH HHS ZIA DK031116Intramural NIH HHS ZIA DK031126
6 · The paper itself

Abstract

The human P2Y

Indexed as

asthmaG protein-coupled receptorinflammationP2Y receptorstructure–activity relationship

Identifiers

PMID40969903
PMCPMC12441858

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.