ReviewFrontiers in pharmacology2025
Natural active herbal monomers for the treatment of thromboembolic diseases: a review.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Integrating Network Pharmacology and Metabolomics to Elucidate the Mechanism of Cryptotanshinone Against Platelet Aggregation.Current issues in molecular biology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thromboembolism is a leading cause of morbidity and mortality worldwide. Current methods of treating thromboembolism include anticoagulant therapy, thrombolytic therapy, and surgical removal of the thrombus. All of these treatments have some drawbacks, such as an increased risk of bleeding, limitation to fresh thrombus, and a high recurrence rate. Therefore, there is an urgent need to find effective and safe drugs for the treatment of thromboembolism. In recent years, it has been found that many natural active herbal monomers exhibit distinct advantages in treating this condition. In this review, the therapeutic effects of effective active monomers from natural herbs on thromboembolism, including flavonoids, polyphenols, alkaloids, terpenoids, saponins, and organic acids, were described. Furthermore, their antioxidant, anti-inflammatory, inhibition of platelet aggregation and antithrombotic effects through nuclear factor NF-κB, ERK1/2, PI3K, Akt and other signaling pathways were systematically summarized. Altogether, this review provides a comprehensive summary of promising therapeutic candidate drugs for the treatment of thromboembolic diseases and aims to guide future preclinical and clinical research for novel, safe and effective antithrombotic therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.