Evidence map›Paper›PMID 40969972›Full record

ArticleAddiction neuroscience2025

The persistent effects of exposure to a predator odor stressor on sensitivity to alcohol.

Ryan E Tyler, Maya N Bluitt, Kalynn J Van Voorhies, Wen Liu, Sarah N Magee, Elisabeth R Pitrolo, Victoria L Cordero, Laura C Ornelas, Caroline G Krieman, Brooke N Bender and 2 more

Abstract read
In one paragraph

Article in Addiction neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ryan E TylerNeuroscience Curriculum, School of Medicine, University of North Carolina - Chapel Hill, Chapel Hill, NC, United States.
Maya N BluittNeuroscience Curriculum, School of Medicine, University of North Carolina - Chapel Hill, Chapel Hill, NC, United States.
Kalynn J Van VoorhiesNeuroscience Curriculum, School of Medicine, University of North Carolina - Chapel Hill, Chapel Hill, NC, United States.
Wen LiuNeuroscience Curriculum, School of Medicine, University of North Carolina - Chapel Hill, Chapel Hill, NC, United States.
Sarah N MageeNeuroscience Curriculum, School of Medicine, University of North Carolina - Chapel Hill, Chapel Hill, NC, United States.
Elisabeth R PitroloBowles Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill, NC, United States.
Victoria L CorderoBowles Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill, NC, United States.
Laura C OrnelasBowles Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill, NC, United States.
Caroline G KriemanBowles Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill, NC, United States.
Brooke N BenderBowles Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill, NC, United States.
Alejandro M MoseraBowles Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill, NC, United States.
Joyce BesheerNeuroscience Curriculum, School of Medicine, University of North Carolina - Chapel Hill, Chapel Hill, NC, United States.ORCID 0000-0001-6187-8376

Funding

SEEDING POSTDOCTORAL INNOVATORS IN RESEARCH &EDUCATIONK12GM000678 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DONALD T LYSLE, Kathryn Joanna Reissner · 1999 to 2026
$30.9M
RESEARCH TRAINING IN THE NEUROSCIENCEST32NS007431 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Juan Song, Mark J. Zylka · 1997 to 2026
$10.0M
Characterization of alcohol self-administration following predator odor exposure: relevance to PTSD-Diversity SupplementR01AA026537 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joyce Besheer · 2017 to 2026
$3.9M
Corticolimbic circuitry in adaptive stress coping behavior and subsequent alcohol drinkingR00AA029730 · NIAAA · UNIVERSITY OF NEW MEXICO · PI Laura C. Ornelas · 2024 to 2026
$733k
Corticolimbic circuitry in adaptive stress coping behavior and subsequent alcohol drinkingK99AA029730 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ORNELAS, LAURA C. · 2022 to 2023
$205k
The early and lasting mechanisms underlying predator odor stressor-induced adaptations to alcohol interoceptive sensitivityF31AA029946 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TYLER, RYAN EDWARD · 2022 to 2023
$57k
NIAAA NIH HHS F31 AA029946NIAAA NIH HHS K99 AA029730NIAAA NIH HHS R00 AA029730NIAAA NIH HHS R01 AA026537NIGMS NIH HHS K12 GM000678NINDS NIH HHS T32 NS007431
6 · The paper itself

Abstract

Traumatic stress is linked to problematic alcohol use, yet its persistent effects on alcohol sensitivity remain unclear. This study examined the long-term effects of traumatic stress on alcohol sensitivity in male and female Long-Evans rats. Rats were trained to discriminate alcohol (2 g/kg, i.g.) from water, and two weeks after a single, inescapable exposure to the predator odor stressor TMT, substitution for an alcohol dose curve and GABA

Indexed as

AlcoholDrug discriminationGABAAPTSDStress

Identifiers

PMID40969972
PMCPMC12442340

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.