Evidence map›Paper›PMID 40970092›Full record

ArticleFrontiers in cell and developmental biology2025

The mechanosensitive protein ANTXR1 is involved in maintaining cartilage homeostasis in post-traumatic osteoarthritis.

Zhuangzhuang Miao, Junjie Liu, Pengfei Cheng, Yinghao Shen, Jiahang Tang, Jiajie Zhu, Weiwei Liu, Xuchang Zhou, Hongying Jing

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhuangzhuang Miao *Graduate School, Harbin Sport University, Harbin, China.
Junjie Liu *Graduate School, Harbin Sport University, Harbin, China.
Pengfei ChengGraduate School, Harbin Sport University, Harbin, China.
Yinghao ShenGraduate School, Harbin Sport University, Harbin, China.
Jiahang TangGraduate School, Harbin Sport University, Harbin, China.
Jiajie ZhuSchool of Graduate Education, Shandong Sport University, Jinan, China.
Weiwei LiuGraduate School, Harbin Sport University, Harbin, China.
Xuchang ZhouSchool of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing, China.
Hongying JingGraduate School, Harbin Sport University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-traumatic osteoarthritis (PTOA) is a degenerative joint disease secondary to joint trauma, such as anterior cruciate ligament (ACL) injury. Our previous study found that the mechanosensitive protein ANTXR1 is involved in the regulation of bone homeostasis, however, whether ANTXR1 is involved in the regulation of cartilage homeostasis in PTOA is unclear. In this study, we focused on the expression of the mechanosensitive protein ANTXR1 in cartilage homeostasis and explored its role in the initiation and progression of PTOA. To investigate the effects of treadmill exercise on bone-cartilage homeostasis, we established models using different exercise intensities (20%, 40%, 60%, 80% of maximal oxygen uptake, VO

Indexed as

anterior cruciate ligament injuryanterior cruciate ligament osteoarthritisANTXR1LRP6osteoarthritistreadmill exercise

Identifiers

PMID40970092
PMCPMC12440867

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.