In one paragraphArticle in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
51 authors.
Tiffany TuComputational Biology and Bioinformatics Program, Duke University, Durham, North Carolina, USA.ORCID 0000-0002-9357-6660 Alejandro OchoaComputational Biology and Bioinformatics Program, Duke University, Durham, North Carolina, USA.ORCID 0000-0003-4928-3403 Amika SoodCenter for Statistical Genetics and Genomics, Duke University, Durham, North Carolina, USA.ORCID 0000-0002-0767-7917 Megan Chryst-StanglDepartment of Pediatrics and Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC.
Brandon LaneDepartment of Pediatrics and Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC.ORCID 0000-0002-1158-1117 Guanghong WuDepartment of Pediatrics and Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC.
Ursula HarperGenomics Core, National Human Genome Research Institute, NIH, Bethesda, MD.
Settara ChandrasekharappaGenomics Core, National Human Genome Research Institute, NIH, Bethesda, MD.ORCID 0000-0002-8084-0530 Christopher EsezoborDepartment of Pediatrics, College of Medicine, University of Lagos, and Lagos University Teaching Hospital, Lagos, Nigeria.ORCID 0000-0003-1736-4794 Adaobi SolarinDepartment of Pediatrics, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria.ORCID 0000-0002-2594-5815 David HooperDepartment of Pediatrics, Cincinnati Children's Hospital Medical, Cincinnati, Ohio, USA.ORCID 0000-0001-8732-4291 Christine SethnaDivision of Pediatric Nephrology, Cohen Children's Medical Center, New Hyde Park, NY, USA.ORCID 0000-0002-7666-5792 Sandra AmaralDivision of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID 0000-0001-7357-242X Mahmoud KallashDivision of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, Ohio.
Priya VergheseDepartment of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-8836-0881 Vikas DharnidharkaDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO.ORCID 0000-0001-8000-1385 Eloise SalmonDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan.
Patricia WengDepartment of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID 0000-0003-2020-2729 Tarak SrivastavaChildren's Mercy Hospital and University of Missouri-Kansas City School of Medicine, Kansas City, Missouri.ORCID 0000-0002-8654-0627 Michael E SeifertDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-0557-6178 Cozumel PruetteJohns Hopkins Pediatrics, Johns Hopkins University School of Medicine, Rubenstein Child Health Building Suite 3057, 200 N Wolfe St, Baltimore, MD, 21287, USA.ORCID 0000-0003-4253-9242 David SelewskiDepartment of Pediatrics, Medical University of South Carolina, Charleston, South Carolina.ORCID 0000-0003-0358-0760 Keisha GibsonDepartment of Pediatrics and Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, US.ORCID 0000-0003-4702-8150 Tracy HunleyDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-8766-551X Shenal ThalgahagodaDepartment of Pediatrics, University of Peradeniya, Peradeniya, Sri Lanka.
Arvind BaggaDepartment of Pediatrics, Division of Nephrology, All India Institute of Medical Science, Ansari Nagar, New Delhi, India.ORCID 0000-0002-7832-684X Aditi SinhaDepartment of Pediatrics, Division of Nephrology, All India Institute of Medical Science, Ansari Nagar, New Delhi, India.ORCID 0000-0002-9566-3370 Larry GreenbaumDivision of Pediatric Nephrology, Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia.ORCID 0000-0002-2490-021X Ali GharaviDivision of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.ORCID 0000-0003-2801-233X Krzysztof KirylukDivision of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.ORCID 0000-0002-5047-6715 Mathias KretzlerDivision of Nephrology, Department of Medicine, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0003-4064-0582 Lisa Guay-WoodfordResearch Institute and Department of Pediatrics, Divisions of Nephrology and Genetics, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0002-6187-3927 Simone Sanna-CherchiDivision of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.ORCID 0000-0002-6185-948X Agnieszka BierzynskaDepartment of Pediatric Nephrology, Bristol Royal Hospital for Children, University Hospitals Bristol and Weston NHS Foundation Trust, Upper Maudlin Street, Bristol BS2 8BJ, UK.ORCID 0000-0002-7878-6096 Ania KoziellDepartment of Pediatric Nephrology, Evelina Children's Hospital, London, UK.
Gavin WelshDepartment of Pediatric Nephrology, Bristol Royal Hospital for Children, University Hospitals Bristol and Weston NHS Foundation Trust, Upper Maudlin Street, Bristol BS2 8BJ, UK.ORCID 0000-0002-2148-6658 Moin SaleemDepartment of Pediatric Nephrology, Bristol Royal Hospital for Children, University Hospitals Bristol and Weston NHS Foundation Trust, Upper Maudlin Street, Bristol BS2 8BJ, UK.ORCID 0000-0002-9808-4518 Charles RotimiCenter for Research for Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, USA.ORCID 0000-0001-5759-053X Eileen ChambersDepartment of Pediatrics and Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC.ORCID 0000-0001-7060-9311 Cliburn ChanComputational Biology and Bioinformatics Program, Duke University, Durham, North Carolina, USA.ORCID 0000-0001-5901-6806 CureGN Consortium
PNRC Glomerular disease group
CIBMTR/NMDP Consortium
Annette JacksonDepartment of Surgery and Immunology, Duke University School of Medicine, Durham, NC.ORCID 0000-0003-2648-2944 Adebowale AdeyemoCenter for Research for Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, USA.ORCID 0000-0002-3105-3231 Rasheed GbadegesinDepartment of Pediatrics and Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC.ORCID 0000-0001-5641-6644 Funding
New York Center for Collaborative Research In Common Disease Genomics: Genome Aggregation and Joint Variant Calling for CCDG Freeze2UM1HG008901 · NHGRI · NEW YORK GENOME CENTER · PI MANIATIS, THOMAS P, WIGLER, MICHAEL H · 2016 to 2020
$56.6MGenetic epidemiology of complex diseasesZIAHG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2009 to 2025
$54.7MCureGNU24DK100845 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CRYSTAL A. GADEGBEKU, Laura H Mariani · 2019 to 2026
$12.1MCureGN-Penn PCCU01DK100846 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LAWRENCE B. HOLZMAN · 2019 to 2026
$8.3MCUREGN 3.0 - Pediatric Nephrology Consortium - PCCU01DK100866 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Laurence A Greenbaum, Jon Klein · 2019 to 2026
$7.7MCureGN-3: UNCPCCU01DK100867 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Vimal Kumar Derebail, Ronald J Falk · 2019 to 2026
$6.7MDefining the Landscape of HLA Risk Alleles in Primary Nephrotic Syndrome and Post Kidney Transplant RecurrenceU01AI152585 · NIAID · DUKE UNIVERSITY · PI GBADEGESIN, RASHEED ADEBAYO, JACKSON, ANNETTE MARIE · 2020 to 2024
$3.7MIntramural NIH HHS ZIA HG200362NHGRI NIH HHS UM1 HG008901NIAID NIH HHS U01 AI152585NIDDK NIH HHS U01 DK100846NIDDK NIH HHS U01 DK100866NIDDK NIH HHS U01 DK100867NIDDK NIH HHS U24 DK100845
6 · The paper itselfAbstract
Introduction: Nephrotic syndrome (NS), a common glomerular disease in children, is classified based on response to corticosteroid therapy as either steroid-sensitive nephrotic syndrome (SSNS), or steroid-resistant nephrotic syndrome (SRNS). However, there are currently no reliable predictors of therapy response at initial clinical presentation. Methods: We conducted genome-wide association studies, developed polygenic risk scores (PRS) for therapy response and analyzed classical HLA alleles in 1,997 (994 discovery and 1,003 replication/validation cohorts) previously unstudied children with NS and 3,558 ancestry-matched controls. Results: A significant association with HLA loci defined by variants in Conclusions: Our findings confirm that SSNS (unlike SRNS) is an immune-mediated HLA-associated disorder. The PRS for therapy response and HLA haplotype can serve as biomarkers and provide a foundation for more accurate diagnoses and tailored and individualized treatment.
Indexed as
HLA haplotypeNephrotic syndromepolygenic risk scoretherapy response
Identifiers
PMID40970117
PMCPMC12443051
What Socratic holds
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LicenceCC BY-NC
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