Evidence map›Paper›PMID 40970206›Full record

ArticleiScience2025

Differential response of human plasmacytoid pre-dendritic cells to SARS-CoV-2 variants.

Daria Kartasheva-Ebertz, Dimitrios Topalis, Claudia Umana-Diaz, Okan Ayas, Laurine Couture, Pierre Tonnerre, Jasna Medvedovic, Laurent Meertens, Vassili Soumelis, Ali Amara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daria Kartasheva-EbertzUniversité Paris Cité, INSERM U976, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France.
Dimitrios TopalisUniversité Paris Cité, Biology of Emerging Viruses Team, INSERM U944/CNRS UMR 7212, Institut de Recherche Saint-Louis, Hôpital Saint Louis, Paris, France.
Claudia Umana-DiazUniversité Paris Cité, Biology of Emerging Viruses Team, INSERM U944/CNRS UMR 7212, Institut de Recherche Saint-Louis, Hôpital Saint Louis, Paris, France.
Okan AyasUniversité Paris Cité, INSERM U976, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France.
Laurine CoutureUniversité Paris Cité, Biology of Emerging Viruses Team, INSERM U944/CNRS UMR 7212, Institut de Recherche Saint-Louis, Hôpital Saint Louis, Paris, France.
Pierre TonnerreUniversité Paris-Cité, INSERM U976, Team ATIP-Avenir, Institut de Recherche Saint-Louis Paris, Paris, France.
Jasna MedvedovicUniversité Paris Cité, INSERM U976, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France.
Laurent MeertensUniversité Paris Cité, Biology of Emerging Viruses Team, INSERM U944/CNRS UMR 7212, Institut de Recherche Saint-Louis, Hôpital Saint Louis, Paris, France.
Vassili SoumelisUniversité Paris Cité, INSERM U976, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France.
Ali AmaraUniversité Paris Cité, Biology of Emerging Viruses Team, INSERM U944/CNRS UMR 7212, Institut de Recherche Saint-Louis, Hôpital Saint Louis, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have been involved in various waves of the COVID-19 pandemic and showed different pathogenicity and inflammatory potential. Whether they can induce different patterns of innate immune activation in antigen-presenting cells is poorly understood. Here, we investigated the ability of primary plasmacytoid pre-dendritic cells (pDC), type 2 dendritic cells (DC2), and monocytes isolated from healthy donors to respond to SARS-CoV-2 variants. Transcriptomic profiling using RNA sequencing revealed that pDC respond differentially to SARS-CoV-2 variants, unlike DC2 and monocytes. Functional studies showed that pDC undergo differential activation programs upon SARS-CoV-2 variant stimulation. The Alpha and Delta variants induced P1-/P2-pDC effector phenotypes, characterized by strong IFN-α production. In contrast, the Omicron variant predominantly triggered a T cell-activating P3 phenotype, with lower IFN-α and IFN-λ production, and stronger proinflammatory and CD4

Indexed as

Immune responseVirology

Identifiers

PMID40970206
PMCPMC12441710

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.