Evidence map›Paper›PMID 40970288›Full record

ArticlePhysiological reports2025

MK2 deficiency decreases mortality in male mice during the inflammatory phase after myocardial infarction.

Joëlle Trépanier, Sherin A Nawaito, Pramod Sahadevan, Fatiha Sahmi, Natacha Duquette, Danielle Gélinas, Marc-Antoine Gillis, Yanfen Shi, Cynthia Torok, Marie-Élaine Clavet-Lanthier and 4 more

Abstract read
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Joëlle TrépanierMontreal Heart Institute, Montréal, Québec, Canada.
Sherin A NawaitoMontreal Heart Institute, Montréal, Québec, Canada.
Pramod SahadevanMontreal Heart Institute, Montréal, Québec, Canada.
Fatiha SahmiMontreal Heart Institute, Montréal, Québec, Canada.
Natacha DuquetteMontreal Heart Institute, Montréal, Québec, Canada.
Danielle GélinasMontreal Heart Institute, Montréal, Québec, Canada.
Marc-Antoine GillisMontreal Heart Institute, Montréal, Québec, Canada.
Yanfen ShiMontreal Heart Institute, Montréal, Québec, Canada.
Cynthia TorokMontreal Heart Institute, Montréal, Québec, Canada.
Marie-Élaine Clavet-LanthierMontreal Heart Institute, Montréal, Québec, Canada.
Matthias GaestelInstitute of Cell Biochemistry, Hannover Medical School, Hannover, Germany.
Martin G SiroisMontreal Heart Institute, Montréal, Québec, Canada.
Jean-Claude TardifMontreal Heart Institute, Montréal, Québec, Canada.
Bruce G AllenMontreal Heart Institute, Montréal, Québec, Canada.ORCID 0000-0001-9000-9495

Funding

Fondation Institut de Cardiologie de Montréal (Montreal Heart Institute Foundation)Heart and Stroke Foundation of Canada (HSF) G-14-0006060Heart and Stroke Foundation of Canada (HSF) G-18-0022227
6 · The paper itself

Abstract

Altering inflammation can impact the recovering heart's structure and function following myocardial infarction (MI). MAP kinase-activated protein kinase 2 (MK2) regulates the stability of several pro-inflammatory cytokines. Hence, this study was to determine if MK2 deficiency impaired the inflammatory phase of post-MI wound repair. Myocardial infarctions were induced by permanent ligation of the left anterior descending coronary artery in 12-week-old male MK2

Indexed as

InflammationIntracellular Signaling Peptides and ProteinsMyocardial InfarctionProtein Serine-Threonine KinasesAnimalsCytokinesMaleMAP-Kinase-Activated Kinase 2MiceMice, Inbred C57BLMice, KnockoutCytokinesIntracellular Signaling Peptides and ProteinsMAP-Kinase-Activated Kinase 2Protein Serine-Threonine KinasescytokineheartinflammationMAPK‐activated protein kinase‐2MK2myocardial infarction

Identifiers

PMID40970288
PMCPMC12447013

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.