Evidence map›Paper›PMID 40970322›Full record

ArticleInternational journal of oncology2025

Cooperation between ZEB2 and SP1 upregulates PD‑L1 and CCL2 to promote the immunosuppressive activity of tumor cells.

Dongjoon Ko, Yunhee Lee, Junghwa Yoon, Eun Kyoung Choi, Donghwan Jang, Semi Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dongjoon KoMicrobiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon 34141, Republic of Korea.
Yunhee LeeMicrobiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon 34141, Republic of Korea.
Junghwa YoonMicrobiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon 34141, Republic of Korea.
Eun Kyoung ChoiMicrobiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon 34141, Republic of Korea.
Donghwan JangMicrobiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon 34141, Republic of Korea.
Semi KimMicrobiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon 34141, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial‑mesenchymal transition (EMT) is implicated in tumor progression and EMT‑inducing transcription factors play multifaceted roles; however, the molecular mechanisms underlying these processes are not well understood. Previously, we showed that ZEB2 acts cooperatively with the transcription factor SP1 to function as a transcriptional activator that promotes cancer cell invasion and survival, as well as angiogenesis. The present study reported a novel role for Zinc Finger E‑Box Binding Homeobox 2 (ZEB2) in conferring immunosuppressive activity on cancer cells, as well as the underlying molecular mechanism. ZEB2 cooperated with SP1 to upregulate transcription of

Indexed as

B7-H1 AntigenChemokine CCL2Sp1 Transcription FactorZinc Finger E-box Binding Homeobox 2AnimalsCell Line, TumorEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansMaleMiceUp-RegulationB7-H1 AntigenCCL2 protein, humanCD274 protein, humanChemokine CCL2SP1 protein, humanSp1 Transcription FactorZEB2 protein, humanZinc Finger E-box Binding Homeobox 2C‑C motif chemokine ligand 2immunosuppressionprogrammed cell death 1 ligand 1SP1SUMOylationZinc Finger E‑Box Binding Homeobox 2

Identifiers

PMID40970322
PMCPMC12456470

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.