Evidence map›Paper›PMID 40970430›Full record

ArticleEpigenomics2025

Increased methylation levels of the

Dijana Majstorović, Andrea Stoccoro, Anita Barišić, Alena Buretić Tomljanović, Marianna Giangreco, Vanessa Nicolì, Fabio Coppedè, Jadranka Vraneković

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PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. International journal of molecular medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dijana MajstorovićFaculty of Medicine, Juraj Dobrila University of Pula, Pula, Croatia.ORCID 0000-0002-2933-7497
Andrea StoccoroDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy.ORCID 0000-0002-6768-8466
Anita BarišićDepartment of Gynaecology and Obstetrics, Clinical Hospital Center Rijeka, Rijeka, Croatia.ORCID 0000-0002-5403-3129
Alena Buretić TomljanovićFaculty of Medicine, Department of Medical Biology and Genetics, University of Rijeka, Rijeka, Croatia.ORCID 0000-0002-9840-1245
Marianna GiangrecoDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy.
Vanessa NicolìDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy.ORCID 0000-0003-2751-7352
Fabio CoppedèDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy.ORCID 0000-0002-3081-6647
Jadranka VranekovićFaculty of Medicine, Department of Medical Biology and Genetics, University of Rijeka, Rijeka, Croatia.ORCID 0000-0001-6365-5686

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsPATIENTS AND

methodsThe study included 118 participants: 59 individuals with DS, 25 of which with CHD, and 59 age and gender matched controls. Genomic DNA was extracted from peripheral blood. Methylation-sensitive high-resolution melting and PCR - RFLP were used to assess methylation and genotyping.

resultsDS individuals showed significantly higher

conclusionWe observed a significant increase in

Indexed as

DNA MethylationDown SyndromeMethylenetetrahydrofolate Reductase (NADPH2)Promoter Regions, GeneticAdolescentAdultCase-Control StudiesChildChild, PreschoolFemaleHeart Defects, CongenitalHumansMalePolymorphism, Single NucleotideYoung AdultMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humancongenital heart defectsDNA methylationDown syndromemethylenetetrahydrofolate reductasesingle nucleotide polymorphisms

Identifiers

PMID40970430
PMCPMC12562786

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.