ArticleJournal of hypertension2026
Relation of carotid-to-femoral pulse wave velocity to aortic stiffness and total arterial compliance in healthy individuals.
Article in Journal of hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarotid-to-femoral pulse wave velocity (c-f PWV) is commonly used to assess large artery stiffness, particularly as a surrogate of aortic stiffness. Given that c-f PWV represents the average stiffness of all main arteries along the carotid-to-femoral arterial pathway, without specifically accounting for the stiffness of the proximal aorta, we hypothesized that c-f PWV may not represent stricto sensu the stiffness of the ascending aorta (AAO), which is the main contributor to total arterial compliance ( CT ).
methodsTo test our hypothesis, we recruited 45 healthy volunteers from different age groups. We evaluated the relation between c-f PWV and different indices of proximal aorta stiffness calculated from distensibility (AAO dist PWV) and characteristic impedance (Zc) in frequency (AAO Z c(f) PWV) and time domain (AAO Zc(t) PWV) and compared their relationships with age and CT . 2D phase contrast MRI was performed to measure AAO flow and cross-sectional area. Tonometry was used to obtain c-f PWV and pressure waveforms.
resultsIn healthy individuals, AAO PWV indices demonstrated a strong relationship with each other ( R ≥ 0.86), but c-f PWV did not show high correlations with AAO PWV indices ( R ≤ 0.50). All AAO PWV indices increased with age ( P ≤ 0.05); however, c-f PWV did not increase from young to middle-aged ( P = 0.13) and middle-aged to old age groups ( P = 0.28). AAO PWV indices correlated well with C T ( R2 ≥ 0.60), whereas c-f PWV did not ( R2 = 0.23).
conclusionThe present study reveals that a complete understanding of large artery stiffness requires the direct assessment of proximal aortic stiffness rather than surrogate indices such as c-f PWV.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.