Evidence map›Paper›PMID 40970721›Full record

ArticleMicrobiology spectrum2025

Increased intestinal permeability and bile acid accumulation via inhibition of the FXR-SHP pathway contribute to coumarin-induced systemic inflammation.

Na Shou, Dandan Wu, Qi Wang, Ping Huang, Qiwen Lin, Senao Hou, Keyi Fu, Wenqian Xu, Jiyu Zhang, Zunji Shi

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Na ShouState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Center for Grassland Microbiome, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China.
Dandan WuState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Center for Grassland Microbiome, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China.
Qi WangState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Center for Grassland Microbiome, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China.
Ping HuangState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Center for Grassland Microbiome, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China.
Qiwen LinState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Center for Grassland Microbiome, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China.
Senao HouState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Center for Grassland Microbiome, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China.
Keyi FuState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Center for Grassland Microbiome, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China.
Wenqian XuState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Center for Grassland Microbiome, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China.
Jiyu ZhangState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Center for Grassland Microbiome, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China.ORCID 0000-0002-3642-373X
Zunji ShiState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Center for Grassland Microbiome, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China.ORCID 0000-0002-1276-6762

Funding

Fundamental Research Funds for the Central Universities lzujbky-2022-ct04Fundamental Research Funds for the Central Universities lzujbky-2023-it33National Natural Science Foundation of China U23A200206
6 · The paper itself

Abstract

Coumarin causes severe poisoning in animals, affecting the development of agriculture and animal husbandry. Coumarin induces hepatotoxicity, but the inflammatory mechanism of coumarin is unclear. Here, we explored the effects of coumarin on systemic and hepatic inflammation. Our study found that coumarin reduced the abundance of

Indexed as

Bile Acids and SaltsCoumarinsInflammationReceptors, Cytoplasmic and NuclearAnimalsGastrointestinal MicrobiomeIntestinal Barrier FunctionIntestinal MucosaIntestinesLipopolysaccharidesLiverMaleMicePermeabilityReceptor, Farnesoid X-ActivatedSignal TransductionBile Acids and SaltscoumarinCoumarinsLipopolysaccharidesReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and Nuclearbile acidscoumarinFxr-Shp pathwaygut microbiotaLPS biosynthesis genes

Identifiers

PMID40970721
PMCPMC12584623

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.