ArticleACS chemical biology2025
Phylogenomic Identification of a Highly Conserved Copper-Binding RiPP Biosynthetic Gene Cluster in Marine
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Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- Cysteine Thioaldehydes: Photolytic Generation, Reactivity, and Biological Implications.Angewandte Chemie (International ed. in English) · 2026Article
- Bis-hydroxylation of Homocitrulline Catalyzed by a Multinuclear Nonheme Iron Oxidative Enzyme during RiPP Biosynthesis.Journal of the American Chemical Society · 2026Article
- Thiooxazole Formation on a NontypeablebioRxiv : the preprint server for biology · 2026Article
- Discovery and Biosynthesis of Nitrilobacillins by Post-Translational Introduction of C-Terminal Nitrile Groups.Journal of the American Chemical Society · 2026Article
- Discovery and Biosynthesis of Nitrilobacillins by Post-translational Introduction of C-Terminal Nitrile Groups.bioRxiv : the preprint server for biology · 2026Article
- Bis-hydroxylation of Homocitrulline Catalyzed by a Multinuclear Nonheme Iron-Dependent Oxidative Enzyme during RiPP Biosynthesis.bioRxiv : the preprint server for biology · 2026Article
- Biosynthesis of Peptidic Thiooxazole Metallophores Installed by Multinuclear Nonheme Iron Enzymes.ACS chemical biology · 2026Article
- Co-opting the bacterial lipoprotein pathway for the biosynthesis of lipidated macrocyclic peptides.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- CURE-ating the Substrate Scope and Functional Residues of Nonheme Iron(II) α-Ketoglutarate-Dependent Hydroxylase BesE.Journal of natural products · 2026Article
- Computational mass spectrometry and genome mining guided discovery of metallophores produced by Microbulbifer.ISME communications · 2026Article
- Biosynthesis of peptidic thiooxazole metallophores installed by multinuclear nonheme iron enzymes.bioRxiv : the preprint server for biology · 2025Article
- Co-opting the bacterial lipoprotein pathway in the biosynthesis of a lipidated macrocyclic peptide.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
32 authors.
Yifan TangSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID 0000-0002-2528-0657
Weimao ZhongSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID 0000-0002-1358-4944
Longping FuSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID 0009-0006-4275-3264
Emmanuel AsanteDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80210, United States.
Anastasiia KostenkoDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80210, United States.
F N U VidyaSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Paige Mandelare-RuizSmithsonian Marine Station, Ft Pierce, Florida 34949, United States.
Tamilore T AdeogunSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Gabriel P AndersonSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Benjamin E EdmondsSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Oscar FangSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Michelle HanSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Alia S HollingsworthSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Amna R InghamSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Carlyn R KirbySchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Alice LandrumSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Connor R MackSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Nikki S NobariSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Emma J OswaldSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Cecilia L PolevoySchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Yasmin SharifianSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Timothy J SoSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Joelee R StokesSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Reniya S ThompsonSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Rishabh VuthamarajuSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Elaine C WangSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
William H YangSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Alison E OnstineSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Valerie J PaulSmithsonian Marine Station, Ft Pierce, Florida 34949, United States.ORCID 0000-0002-4691-1569
Ronghu WuSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID 0000-0001-9493-9462
Allegra T AronDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80210, United States.
Vinayak AgarwalSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID 0000-0002-2517-589X
Funding
Microbiota Metallophores: Probing Interactions and Nutrient Dynamics of the Human GutR35GM155026 · NIGMS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI Allegra Aron · 2024 to 2026
$1.1MCharacterizing extracellular glycoproteins and unraveling their functionsR35GM156318 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI Ronghu Wu · 2025 to 2026
$1.0MNational Science Foundation CHE-2238650NIGMS NIH HHS R35 GM155026NIGMS NIH HHS R35 GM156318
Abstract
Conserved biosynthetic gene clusters (BGCs) are often tied to the production of natural products that perform critical functions in an organism's physiology and ecological interactions. Here, by phylogenetic analysis across the bacterial genus, we report the obligate conservation of a BGC in genomes of cosmopolitan marine
Indexed as
CopperGammaproteobacteriaMultigene FamilyGenome, BacterialPhylogenyCopper
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.