ArticleCell reports2025
Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional deficits in Down syndrome.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Astrocyte reactivity by alcohol dependence in the central amygdala.Brain, behavior, and immunity · 2026Article
- Irisin-BDNF axis mediates muscle-brain communication: a complete molecular cascade and potential bidirectional feedback from peripheral activation to central protection.Biogerontology · 2026Review
- Pleiotrophin regulates presynaptic assembly and function through heparan sulfate-dependent binding to neurexin1.Cell reports · 2026Article
- The Molecular Machinery of Synaptic Plasticity and Its Potential Role in the Aetiology of Schizophrenia.Molecular neurobiology · 2026Review
- Astrocyte-driven multicellular mechanisms of CNS repair and cerebroprotection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Suppression of astrocyte BMP signaling improves molecular signatures and functional deficits in a fragile X syndrome mouse model.Nature communications · 2026Article
- Astrocyte Reactivity by Alcohol Dependence in the Central Amygdala.bioRxiv : the preprint server for biology · 2026Article
- Article
- Chimeric brain models to study human glial-neuronal and macroglial-microglial interactions.Cell reports · 2026Article
- Glia detect and transiently protect against dendrite substructure disruption in C. elegans.Nature communications · 2025Article
- Human-Mouse Chimeric Brain Models to Study Human Glial-Neuronal and Macroglial-Microglial Interactions.bioRxiv : the preprint server for biology · 2024Article
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7 authors.
Funding
Abstract
Neuronal dendrite patterning and synapse formation are tightly regulated during development to promote proper connectivity. Here, we identify downregulation of pleiotrophin, a secreted molecule enriched in astrocytes, as a major contributor to dendrite and synapse deficits in the Ts65Dn mouse model of Down syndrome (DS). We find overlapping deficits in neuronal dendrites and spines in Ts65Dn mutant and pleiotrophin knockout mice. We show that targeting pleiotrophin overexpression to astrocytes in adult Ts65Dn mice in vivo can rescue dendrite morphology as well as restore spine density, synapse number, and plasticity deficits in the hippocampus. Moreover, pleiotrophin promotes dendrite outgrowth in cultured Ts65Dn neurons through Alk-Akt signaling. Our findings highlight dysregulated astrocyte protein secretion as a contributing factor to DS and identify pleiotrophin as a plasticity-inducing molecule that can be used to promote proper circuit connectivity, importantly, at later stages of development after typical periods of circuit refinement have been completed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.