Evidence mapPaperPMID 40972715Full record

ReviewJournal of advanced research2026

Gut microbiota: A key player for soluble dietary fiber in regulating inflammatory disease.

Linkai Qu, Ruining Zhang, Ziyu Chu, Jiapei Cai, Yuhang He, Xinyu Zhang, Jiuxi Liu, Xufeng Xie, Yongguo Cao

Abstract readReview
In one paragraph

Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Linkai QuState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Ruining ZhangState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Ziyu ChuState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Jiapei CaiState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Yuhang HeState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Xinyu ZhangState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Jiuxi LiuState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Xufeng XieState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China. Electronic address: xiexf@jlu.edu.cn.
Yongguo CaoState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China. Electronic address: ygcao82@jlu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Soluble dietary fiber (SDF) plays a significant role in modulating immune responses, particularly in the context of inflammatory diseases. SDF enhances intestinal barrier integrity and regulates immune function by modulating the composition of the gut microbiota and increasing the production of beneficial microbial metabolites, such as short-chain fatty acids (SCFAs), 3-hydroxyoctadecaenoic acid, pentadecanoic acid, and bile acids. Current evidence suggests that SDF holds therapeutic potential in managing chronic inflammatory diseases such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and metabolic dysfunction-associated steatohepatitis (MASH). Despite these promising findings, the mechanisms by which SDF exerts its effects, particularly in distal organs and neuroinflammatory conditions, remain poorly understood. This review explores the mechanistic pathways by which SDF modulates immune regulation and highlights the current challenges and future strategies for optimizing its clinical application in treating inflammatory diseases.

Indexed as

Dietary FiberGastrointestinal MicrobiomeInflammationInflammatory Bowel DiseasesAnimalsFatty Acids, VolatileHumansIntestinal Barrier FunctionIrritable Bowel SyndromeDietary FiberFatty Acids, VolatileGut-brain axisGut liver axisGut microbiotaInflammatory bowel diseaseShort-chain fatty acidsSoluble dietary fiber

Identifiers

PMID40972715
PMCPMC13227257

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.