ArticleThe Journal of allergy and clinical immunology2026
Unraveling mechanisms of allergen sensitization and allergic rhinitis via the nasal transcriptome.
Article in The Journal of allergy and clinical immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A Comprehensive Review of Natural Products Against Allergic Rhinitis and Asthma: From Sensitization to Chronic Remodeling.International journal of molecular sciences · 2026Review
- Molecular Signatures of Aeroallergen Sensitization in Pediatric Populations: A Comparative Study Across Spanish Cities.International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundAllergen sensitization is a critical early step in the pathogenesis of allergic disease. Different allergens likely trigger distinct immune pathways in the nasal epithelium.
objectiveOur aim was to examine molecular mechanisms in the nasal epithelium for sensitization to different allergens.
methodsWe recruited 301 participants and profiled their sensitization to 10 allergens and nasal epithelial transcriptome. Differential expression, gene ontology, causal network, and key driver analyses were performed to identify molecular processes underlying sensitization to indoor allergens, pollens, and pet allergens, as well as for allergic rhinitis (AR).
resultsThe cohort was 48.8% female, with a mean age of 13.2 years (SD = 4.1 years). Most of the cohort was sensitized to at least 1 allergen, with 74.1% sensitized to an indoor allergen, 60.1% pollen sensitized, and 68.1% pet sensitized. In all, 51.8% of the cohort had AR. Using a discovery and test set framework for rigor, we identified and validated 185 transcripts associated with allergen sensitization. Probabilistic causal network and key driver analyses identified a network for allergen sensitization spanning 4 subnetworks for lymphocyte chemotaxis, mast cell, IL-4, and antiviral response. Although the key drivers and transcripts for indoor allergen sensitization mapped to the lymphocyte chemotaxis and antiviral response subnetworks, those for pollen sensitization mapped to the mast cell and IL-4 subnetworks. Pet sensitization mapped to lymphocyte chemotaxis, mast cell, and IL-4. The key drivers for AR significantly overlapped with those for allergen sensitization.
conclusionCausal network analysis of nasal transcriptome revealed allergen-specific biologic processes and key drivers underlying sensitization and AR.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.