Evidence map›Paper›PMID 40973137›Full record

ArticleThe Journal of physiology2025

The Christianson syndrome protein, sodium hydrogen exchanger isoform 6, is required for fat accumulation.

Ruby Gupta, Allatah X Mekile, Rachana L Patnayak, Monish Ram Makena, Ray Wesley Bowman, Cory J White, Damaris N Lorenzo, Rajini Rao

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Recycling Endosomal (NaActa physiologica (Oxford, England) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ruby GuptaDepartment of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-8101-5930
Allatah X MekileDepartment of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-3279-6288
Rachana L PatnayakDepartment of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Monish Ram MakenaDepartment of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ray Wesley BowmanDepartment of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Cory J WhiteDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-3350-2835
Damaris N LorenzoDepartment of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-6856-2988
Rajini RaoDepartment of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-1833-5971

Funding

Mechanism and function of intracellular sodium-proton exchangersR01GM147197 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KRISHNAN, YAMUNA, MIRSHAHI, TOORAJ · 2022 to 2025
$2.4M
Evaluating Changes to the Metabolic Profile of the Central Nervous System due to Active NeuroHIV InfectionK00NS118713 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WHITE, CORY JUSTIN · 2021 to 2025
$391k
Impact of Brain Lipid Dysregulation on Bioenergetics and Neurologic FunctionF99NS118713 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WHITE, CORY JUSTIN · 2020 to 2020
$47k
NIGMS NIH HHS R01 GM147197NINDS NIH HHS F99 NS118713NINDS NIH HHS K00 NS118713
6 · The paper itself

Abstract

Mutations in NHE6 (human gene name SLC9A6) lead to the rare X-linked disorder Christianson syndrome (CS) characterized by intellectual disability, autism and ataxia. NHE6 is a Na

Indexed as

Adipose TissueAtaxiaGenetic Diseases, X-LinkedIntellectual DisabilityMuscle HypotoniaSodium-Hydrogen Exchangers3T3-L1 CellsAdipocytesAnimalsDiet, High-FatEpilepsyGlucoseMaleMiceMice, Inbred C57BLMice, KnockoutGlucoseNHE6 protein, mouseSodium-Hydrogen Exchangersendosomesfat dropletsGLUT4insulininsulin receptorNa+/H+ exchanger

Identifiers

PMID40973137
PMCPMC12645559

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.