ArticleJournal of animal science2025
Genomic study for pregnancy loss in Brahman cattle.
Article in Journal of animal science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Genetic associations between pregnancy loss and economically important traits in Nellore cattle.Journal of animal science · 2026Article
- Genetic and environmental factors affecting pregnancy loss in Nellore cattle: insights from a large-scale Brazilian field database.Journal of animal science · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reproduction has major influence on productivity of beef cattle operations. Maintaining an animal in the herd for an extended period without producing a marketable product can result in significant economic losses, compromising the efficiency of the production system. Understanding genetic variation's role in pregnancy loss (PL) is crucial for improving reproductive success in cattle. Identifying genomic regions that influence embryo and fetal survival, as well as pinpointing candidate genes associated with PL, can enhance breeding strategies. The objective of this study was to estimate variance components and investigate genetic factors associated with PL in Brahman cattle. Phenotypic records consisted of 29,905 pregnancy (28,691) and abortion (1,214) records from nulliparous, primiparous, and multiparous cows. A total of 921 animals were genotyped using a medium-density SNP chip (∼52K markers). Variance components were estimated using a threshold model to assess the binary response to PL through a single-step genomic BLUP procedure. The heritability estimate for PL was low (0.11), but the presence of genetic variance suggests that selection for improved reproductive performance is feasible. Genome-wide association analyses identified 17 candidate regions containing 92 genes. Regions on BTA4, 7, 8, 9, 11, 12, 16, 18, 19, 21, 22, and 29 harbored genes associated with embryonic development and implantation, fertilization, G protein-coupled receptors, embryonic brain development, olfactory receptor activity, and calcium signaling. Orthologous genes were also identified in humans (Homo sapiens), rats (Rattus norvegicus), and mice (Mus musculus). The candidate regions reported in this study provide insights for identifying and selecting animals with improved reproductive performance, ultimately enhancing the productivity of Brahman cattle. Moreover, our findings contribute to a better understanding of the genetic and physiological mechanisms underlying pregnancy retention in beef cattle.
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Registered trials
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