Evidence map›Paper›PMID 40973907›Full record

ArticleGeroScience2026

Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice.

Randy Strong, James F Nelson, Molly A Bogue, Jerry R Colca, Martin Denzel, Vivian Diaz, Brian N Finck, Vadim N Gladyshev, Steve Horvath, Nisi Jiang and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Randy Strong *Geriatric Research, Education and Clinical Center and Research Service, Department of Pharmacology, Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
James F NelsonDepartment of Cellular and Integrative Physiology and Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA. nelsonj@uthscsa.edu.ORCID http://orcid.org/0000-0002-7439-3033
Molly A BogueThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Jerry R ColcaCirius Therapeutics, Inc, Kalamazoo, MI, USA.
Martin DenzelMax Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9B, 50931, Cologne, Germany.
Vivian DiazDepartment of Cellular and Integrative Physiology and Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
Brian N FinckDivision of Nutritional Sciences and Obesity Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Vadim N GladyshevBrigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Steve HorvathHuman Genetics, David Geffen School of Medicine, UCLA. Epigenetic Clock Development Foundation, Los Angeles, CA, 90095, USA.
Nisi JiangDepartment of Cellular and Integrative Physiology and Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
Tracy KellerDepartment of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, 02115, USA.
Rolf F KletzienDepartment of Biomedical Sciences, Metabolic Solutions Development Company (MSDC), Western Michigan University School of Medicine, KalamazooGrand Rapids, MI 49007.MI 49546 , USA.
Ron KorstanjeThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Navasuja KumarDivision of Geriatric and Palliative Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Christiaan LeeuwenburghInstitute On Aging, Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, 32611, USA.
Elizabeth FernandezGeriatric Research, Education and Clinical Center and Research Service, Department of Pharmacology, Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
Andrzej GaleckiDepartments of Internal Medicine and Biostatistics, School of Medicine and School of Public Health, University of Michigan, Ann Arbor, MI, 48109-2200, USA.
Brett GinsburgDepartment of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
Melissa HanDepartment of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, 48109, USA.
Catherine KaczorowskiDepartment of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA.
Scott LeiserDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Marisa Lopez-CruzanDepartment of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
Ken RajAltos Labs, Cambridge Institute, Granta Park, Cambridgeshire, CB21 6GP, UK.
Peter C ReifsnyderThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Nadia A RosenthalThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Susanna RosiAltos Labs, Bay Area Institute, 13-Island Dr, Redwood City, CA, 94065, USA.
Anastasia ShindyapinaBrigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Peter StacpooleDepartment of Medicine. Division of Endocrinology, Diabetes and Metabolism, University of Florida. , 1600 SW Archer Road Gainesville, Florida, 32610-0226, USA.
Adam B SalmonGeriatric Research, Education and Clinical Center, Department of Molecular Medicine, Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
Alexander TyshkovskiyBrigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Peter WalterDept of Biochemistry & Biophysics, Howard Hughes Medical Institute, University of California San Francisco, MC2200. 600 16Th St, N316, San Francisco, CA, 94143, USA.
Malcolm WhitmanDepartment of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, 02115, USA.
Richard A Miller *Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, 48109, USA.
David E Harrison *The Jackson Laboratory, Bar Harbor, ME, 04609, USA.

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Anna Karolina Palucka · 1985 to 2026
$61.9M
TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Xianlin Han · 1995 to 2026
$30.6M
Interventions That Retard Mammalian AgingU01AG022308 · NIA · JACKSON LABORATORY · PI Ronny Korstanje · 2003 to 2026
$30.5M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lona Mody, RAYMOND L YUNG · 2004 to 2026
$29.2M
Center for Testing Potential Anti-Aging InterventionsU01AG022307 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI RANDY STRONG, Adam Salmon · 2004 to 2026
$26.3M
Laboratory for Anti-Geric Testing, Evaluation and ResearchU01AG022303 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RICHARD A MILLER · 2003 to 2026
$25.4M
Mouse Phenome Database: NIA Interventions Testing Program Data Coordinating CenterU24AG066346 · NIA · JACKSON LABORATORY · PI Elissa J Chesler · 2019 to 2026
$1.7M
Division of Cancer Epidemiology and Genetics, National Cancer Institute CA034196NCI NIH HHS P30 CA034196NIA NIH HHS AG0222303NIA NIH HHS AG0222307NIA NIH HHS AG022308NIA NIH HHS AG024824NIA NIH HHS AG066346NIA NIH HHS P30 AG013319NIA NIH HHS P30 AG024824NIA NIH HHS U01 AG022303NIA NIH HHS U01 AG022307NIA NIH HHS U01 AG022308NIA NIH HHS U24 AG066346
6 · The paper itself

Abstract

Mice bred in 2021 were tested by the Interventions Testing Program (ITP) for possible lifespan benefits of 2BAct (2BA), dichloroacetate (DCA), Epicatechin (EPI), Forskolin (FSK), Halofuginone (HAL) and Mitoglitazone (MIT). All agents were administered in the diet ad libitum beginning at 7 months of age. In male mice, EPI increased median lifespan by ~ 5%, and HAL and MIT each increased median lifespan by ~ 9%. EPI and HAL, but not MIT, increased 90% survival. In addition to adding 3 new agents to the list of interventions identified by the ITP that extend lifespan, this report continues the strong male bias in the efficacy of life-extending drugs identified so far.

Indexed as

CatechinLongevityPiperidinesQuinazolinonesAnimalsFemaleMaleMiceSex FactorsCatechinhalofuginonePiperidinesQuinazolinonesEpicatechinGenetically heterogeneous miceHalofuginoneMitoglitazoneSurvival

Identifiers

PMID40973907
PMCPMC13355999

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.