Evidence map›Paper›PMID 40973940›Full record

ArticleChinese medicine2025

Buyang Huanwu Decoction enhances hippocampal-cortical connectivity remodeling via sonic hedgehog signaling to ameliorate memory dysfunction in cerebral ischemic rats.

Yun Lu, Ziyue Lin, Hanyu Wang, Yuming Zhuang, Jingting Jia, Yuxuan Wang, Le Yang, Manzhong Li, Mingcong Li, Binbin Nie and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chinese medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yun Lu *Department of Chinese Pharmacy, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China.
Ziyue Lin *School of Traditional Chinese Medicine, Capital Medical University, #10, Youanmenwai Xitoutiao, Fengtai District, Beijing, 100069, China.
Hanyu WangSchool of Traditional Chinese Medicine, Capital Medical University, #10, Youanmenwai Xitoutiao, Fengtai District, Beijing, 100069, China.
Yuming ZhuangSchool of Traditional Chinese Medicine, Capital Medical University, #10, Youanmenwai Xitoutiao, Fengtai District, Beijing, 100069, China.
Jingting JiaSchool of Traditional Chinese Medicine, Capital Medical University, #10, Youanmenwai Xitoutiao, Fengtai District, Beijing, 100069, China.
Yuxuan WangSchool of Traditional Chinese Medicine, Capital Medical University, #10, Youanmenwai Xitoutiao, Fengtai District, Beijing, 100069, China.
Le YangDepartment of Pharmacy, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116023, China.
Manzhong LiDepartment of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
Mingcong LiSchool of Traditional Chinese Medicine, Capital Medical University, #10, Youanmenwai Xitoutiao, Fengtai District, Beijing, 100069, China.
Binbin NieBeijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
Rui ZhangDepartment of Chinese Pharmacy, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China.
Xu PanDepartment of Chinese Pharmacy, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China.
Jianfeng LeiMedical Imaging Laboratory of Core Facility Center, Capital Medical University, Beijing, 100069, China.
Haiyan ZouSchool of Traditional Chinese Medicine, Capital Medical University, #10, Youanmenwai Xitoutiao, Fengtai District, Beijing, 100069, China. zouhy@ccmu.edu.cn.
Hui ZhaoSchool of Traditional Chinese Medicine, Capital Medical University, #10, Youanmenwai Xitoutiao, Fengtai District, Beijing, 100069, China. zhaohuishouyi@ccmu.edu.cn.

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 82174471
6 · The paper itself

Abstract

backgroundAlthough Buyang Huanwu Decoction (BHD) has been shown to promote functional recovery of memory following ischemic stroke, the precise mechanisms underlying its therapeutic effects remain incompletely understood. This study aimed to investigate the impact of BHD on hippocampal-cortical connectivity and elucidate the associated neurobiological mechanisms mediating its restorative effects.

methodsA permanent middle cerebral artery occlusion (MCAO) rat model was established to simulate ischemic stroke conditions for subsequent experimental analyses. MCAO rats received daily intragastric administration of BHD over a 30-day treatment period. Cognitive performance, specifically spatial learning and memory, was assessed using the Morris water maze (MWM) test. Structural alterations in the hippocampus and cortex were quantified through magnetic resonance imaging (MRI), while functional neuronal activity was evaluated using blood-oxygen-level-dependent (BOLD) imaging, including amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) analyses. Seed-based functional connectivity analysis derived from BOLD signals was employed to investigate dynamic changes in hippocampocortical connectivity. Additionally, the involvement of the Sonic hedgehog (Shh) signaling pathway was examined using Western blotting to elucidate potential molecular mechanisms underlying the therapeutic effects of BHD.

resultsTherapeutic administration of BHD significantly ameliorated ischemia-induced memory impairments, attenuated structural damage in hippocampal and cortical regions, and restored neuronal activity levels in the post-stroke hippocampal regions. Notably, BHD treatment promoted functional reorganization of hippocampal-cortical connectivity, concomitant with the modulation of the Shh signaling pathway in both hippocampal and cortical regions.

conclusionsThe treatment with BHD facilitated the remodeling of the connectivity between the hippocampus and cortex, and ultimately alleviated memory dysfunction following stroke. These findings hold great promise in promoting the development of BHD research and enhancing its clinical utility.

Indexed as

Buyang Huanwu DecoctionHippocampal-cortical connectivityNeurogenesisPost-stroke memory dysfunctionSonic hedgehog signaling pathway

Identifiers

PMID40973940
PMCPMC12447606

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.