Evidence map›Paper›PMID 40974255›Full record

Observational studyPain management2025

Chronic pain prevalence and severity in females before & after menopause versus males in a large multi-center database.

Adam Ricker, Nicole Farley, Jesse J McClure, Lisa Goudman, Deepak Berwal, Olga Khazen, Ilknur Telkes, Umm E Hani Abdullah, Candy Wilson, Julie G Pilitsis

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pain management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adam RickerCharles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
Nicole FarleyCharles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
Jesse J McClureCharles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
Lisa GoudmanCharles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
Deepak BerwalCharles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
Olga KhazenCharles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
Ilknur TelkesDepartment of Neurosurgery, University of Arizona College of Medicine, Tucson, AZ, USA.
Umm E Hani AbdullahCharles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
Candy WilsonChristine E. Lynn College of Nursing, Florida Atlantic University, Boca Raton, FL, USA.
Julie G PilitsisDepartment of Neurosurgery, University of Arizona College of Medicine, Tucson, AZ, USA.ORCID 0000-0002-6488-9692

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThis observational study aimed to explore the prevalence and severity of chronic pain in menopausal-aged females. MATERIALS &

methodsWe identified participants in the NIH-sponsored All of Us database with a diagnosis of chronic pain. We examined the severity of pain based on numeric rating scale score (NRS). Among those with chronic pain, we generated four sub-cohorts: females ≥ 51 years old who were menopausal, females 18-50 years who were considered pre-menopausal, and age matched male cohorts.

resultsThe 53,289 participants were separated into four cohorts by age and sex: females 18-50 (10,269), females ≥ 51 (20,182), males 18-50 (4,989), and males ≥ 51 (17,849). Both older females and older males had lower pain levels than the sex-matched 18-50 group (

conclusionsWe found that independent of sex, NRS scores were lower in older adults compared to younger cohorts. Older women however had more pain than their male counterparts. These findings have implications for the design of patient-tailored therapeutic treatments and warrant further exploration of physiological and psychosocial causes.

Indexed as

Chronic PainMenopauseAdolescentAdultAgedAge FactorsDatabases, FactualFemaleHumansMaleMiddle AgedPain MeasurementPrevalenceSeverity of Illness IndexSex FactorsUnited Statesall of usChronic painMenopausenumeric rating scalepain severity

Identifiers

PMID40974255
PMCPMC12674445

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.