Evidence map›Paper›PMID 40974632›Full record

GuidelineThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

Brazilian task force for the management of mucormycosis.

Patrick Leon de Godoy Macedo, Mariane Taborda, Vítor Falcão de Oliveira, Adriana Satie Gonçalves Kono Magri, Lígia Lins Frutuoso, Gideane Mendes de Oliveira, Sinaida T Martins, Daniel Wagner de Castro Lima Santos, Fabianne Altruda de Moraes Costa Carlesse, Francelise Bridi Cavassin and 14 more

Abstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Patrick Leon de Godoy MacedoHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Departamento de Infectologia e Medicina Tropical, São Paulo, SP, Brazil.
Mariane TabordaHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Departamento de Infectologia e Medicina Tropical, São Paulo, SP, Brazil.
Vítor Falcão de OliveiraHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Departamento de Infectologia e Medicina Tropical, São Paulo, SP, Brazil.
Adriana Satie Gonçalves Kono MagriHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Departamento de Infectologia e Medicina Tropical, São Paulo, SP, Brazil.
Lígia Lins FrutuosoMinistério da Saúde, Coordenação Geral de Vigilância da Tuberculose, Micoses Endêmicas e Micobactérias não Tuberculosas (CGTM/DATHI/SVSA/MS), Brasília, DF, Brazil.
Gideane Mendes de OliveiraMinistério da Saúde, Coordenação Geral de Vigilância da Tuberculose, Micoses Endêmicas e Micobactérias não Tuberculosas (CGTM/DATHI/SVSA/MS), Brasília, DF, Brazil.
Sinaida T MartinsMinistério da Saúde, Coordenação Geral de Vigilância da Tuberculose, Micoses Endêmicas e Micobactérias não Tuberculosas (CGTM/DATHI/SVSA/MS), Brasília, DF, Brazil.
Daniel Wagner de Castro Lima SantosHospital Universitário da Universidade Federal do Maranhão (HU-UFMA/EBSERH), Departamento de Moléstias Infecciosas, São Luís, MA, Brazil; Rede D'Or, Hospital UDI, Intituto D'Or de Pesquisa e Ensino (IDOR), São Luís, MA, Brazil.
Fabianne Altruda de Moraes Costa CarlesseUniversidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, SP, Brazil; Universidade Federal de São Paulo, Instituto de Oncologia Pediátrica (IOP) GRAACC/UNIFESP, São Paulo, SP, Brazil.
Francelise Bridi CavassinFaculdades Pequeno Príncipe, Curitiba, PR, Brazil.
Kelsen Dantas EulálioUniversidade Federal do Piauí, Departamento de Doenças Infecciosas e Parasitárias, Terezina, PI, Brazil.
Marcia Lazera AndréaFundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Micologia, Rio de Janeiro, RJ, Brazil.
Andréa d'Avila FreitasFundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Micologia, Rio de Janeiro, RJ, Brazil.
José Ernesto VidalHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Departamento de Infectologia e Medicina Tropical, São Paulo, SP, Brazil; Instituto de Infectologia Emílio Ribas, Departamento de Neurologia, São Paulo, SP, Brazil.
Dayvison Francis Saraiva FreitasFundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Pesquisa Clínica em Dermatologia Infecciosa, Rio de Janeiro, RJ, Brazil.
Marcia GarnicaUniversidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Terezinha do Menino Jesus Silva LeitãoUniversidade Federal do Ceará, Hospital São José de Doenças Infecciosas, Departamento de Saúde Comunitária, Fortaleza, CE, Brazil.
Rosely Maria Zancopé-OliveiraFundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Micologia, Rio de Janeiro, RJ, Brazil.
Marcia de Souza Carvalho MelhemUniversidade Federal do Mato Grosso do Sul, Faculdade de Medicina, Campo Grande, MS, Brazil; Universidade de São Paulo, Faculdade de Medicina, Laboratório de Investigação Médica LIM53, São Paulo, SP, Brazil.
Flavio Queiroz TellesFaculdades Pequeno Príncipe, Curitiba, PR, Brazil.
Maria Aparecida Shikanai-YasudaHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Departamento de Infectologia e Medicina Tropical, São Paulo, SP, Brazil.
Fernanda Dockhorn CostaMinistério da Saúde, Coordenação Geral de Vigilância da Tuberculose, Micoses Endêmicas e Micobactérias não Tuberculosas (CGTM/DATHI/SVSA/MS), Brasília, DF, Brazil.
Maria Adelaide MillingtonMinistério da Saúde, Coordenação Geral de Vigilância da Tuberculose, Micoses Endêmicas e Micobactérias não Tuberculosas (CGTM/DATHI/SVSA/MS), Brasília, DF, Brazil.
Marcello Mihailenko Chaves MagriHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Departamento de Infectologia e Medicina Tropical, São Paulo, SP, Brazil. Electronic address: mmcmagri@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMucormycosis is a rare but life‑threatening fungal infection that has shown an increased incidence in Brazil, especially during the COVID‑19 pandemic.

objectiveTo provide an evidence‑based, context‑specific guideline for the diagnosis and management of mucormycosis within the Brazilian healthcare system. CLINICAL FEATURES: Rhino‑orbito‑cerebral disease predominates, followed by pulmonary, cutaneous, gastrointestinal and disseminated forms; delayed recognition dramatically increases mortality. EPIDEMIOLOGY: The global incidence of mucormycosis is increasing, particularly among patients with diabetes mellitus, hematologic malignancies, transplantation, and corticosteroid exposure. The most frequently isolated species is Rhizopus arrhizus, and regional variations in species distribution may be present. In Brazil, comprehensive epidemiological data remain scarce. TREATMENT: Early, aggressive surgical debridement plus induction with liposomal amphotericin B (5-10 mg/kg/day) followed by isavuconazole or posaconazole is recommended; strict control of hyperglycemia and immunosuppression is essential.

conclusionStandardized national guidance, improved rapid diagnostics, systematic surveillance and equitable drug availability are critical to reduce Brazil's mucormycosis burden.

Indexed as

Antifungal AgentsMucormycosisBrazilCOVID-19HumansAntifungal AgentsIsavuconazoleLiposomal amphotericin BMinistry of healthMucormycosisSurgical debridementTask force

Identifiers

PMID40974632
PMCPMC12481069

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.