Evidence map›Paper›PMID 40974863›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2025

Neurophysiological changes associated with dysglycemia in term neonates with neonatal encephalopathy.

Jessy Parokaran Varghese, Elana F Pinchefsky, Saeed Montazeri, Daphne Kamino, Cecil D Hahn, Sampsa Vanhatalo, Emily Wy Tam

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Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jessy Parokaran VargheseNeurosciences and Mental Health Program, Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Elana F PinchefskyDepartment of Pediatrics, Division of Neurology, Centre Hospitalier Universitaire Sainte-Justine and the University of Montreal, Montreal, QC, Canada.
Saeed MontazeriDepartment of Clinical Neurophysiology HUS Medical Imaging Center, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Daphne KaminoNeurosciences and Mental Health Program, Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Cecil D HahnNeurosciences and Mental Health Program, Hospital for Sick Children Research Institute, Toronto, ON, Canada; Department of Pediatrics, Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
Sampsa VanhataloDepartment of Clinical Neurophysiology HUS Medical Imaging Center, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Emily Wy TamNeurosciences and Mental Health Program, Hospital for Sick Children Research Institute, Toronto, ON, Canada; Department of Pediatrics, Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address: emily.tam@utoronto.ca.

Funding

Neurological Outcome of Glycemia in Neonatal EncephalopathyR01HD101419 · NICHD · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI TAM, EMILY WING YUN · 2020 to 2024
$790k
NICHD NIH HHS R01 HD101419
6 · The paper itself

Abstract

objectiveTo investigate the relationship between hypo/hyperglycemia and EEG measures in term neonates with neonatal encephalopathy (NE) treated with therapeutic hypothermia (TH).

methodsNinety-six neonates underwent concurrent continuous glucose monitoring (CGM) and EEG for 48 h within the first 72 h of life. Five-minute epochs of hypoglycemia (≤2.6 mmol/L; ≤47 mg/dL) and hyperglycemia (>10.1 mmol/L; >182 mg/dL) were identified. Continuous EEG data was segmented into 5-min epochs corresponding to 5-min CGM data. Visual EEG background score and 22 computational EEG measures were estimated and their relationship to dysglycemia was assessed after adjusting for hypoxia-ischemia severity and multiple testing.

resultsAmong the 96 neonates, 12 had hypoglycemia, 16 had hyperglycemia, including 1 with both during the recording period. In the adjusted analyses, hyperglycemic epochs were associated with worse visual background scores (1.2, 95 %CI 0.51-1.89, q = 0.003) and 11 computational EEG measures. In contrast, hypoglycemic epochs were not associated with a significant change in visual background scores (-0.28, 95 %CI -0.66 - -0.10, q = 0.549), and were only associated with one computational EEG measure.

conclusionsHyperglycemia is temporally associated with changes in brain function in term neonates with NE treated with TH. SIGNIFICANCE: This temporal relationship suggests high glucose levels may contribute directly to brain injury after NE.

Indexed as

Blood GlucoseBrain DiseasesHyperglycemiaHypoglycemiaHypoxia-Ischemia, BrainElectroencephalographyFemaleHumansHypothermia, InducedInfant, NewbornMaleBlood GlucoseContinuous glucose monitoringEEGHyperglycemiaHypoglycemiaNeonatal encephalopathyTherapeutic hypothermia

Identifiers

PMID40974863
PMCPMC12626053

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.