Evidence map›Paper›PMID 40975127›Full record

ReviewJournal of advanced research2026

Dynamic remodeling of amino acid metabolism in tumor-associated macrophages: Fueling immunosuppression, reshaping tumor niches, and unlocking metabolic checkpoints.

Beibei Ran, Lingjun Xiao, Yan Liu, Chenglin Zhang, Lingkai Kong, Yuxin Zhang, Xiaosong Gu, Chunping Jiang, Junhua Wu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Beibei RanState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China; Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250021, China; "Nanjing University-Gulou" Joint Laboratory of AI and Healthcare BigData, National Institute of Healthcare Data Science at Nanjing University, School of Life Sciences, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China.
Lingjun XiaoState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China; Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250021, China; "Nanjing University-Gulou" Joint Laboratory of AI and Healthcare BigData, National Institute of Healthcare Data Science at Nanjing University, School of Life Sciences, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China.
Yan LiuState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China; Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250021, China; "Nanjing University-Gulou" Joint Laboratory of AI and Healthcare BigData, National Institute of Healthcare Data Science at Nanjing University, School of Life Sciences, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China.
Chenglin ZhangState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China; Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250021, China; "Nanjing University-Gulou" Joint Laboratory of AI and Healthcare BigData, National Institute of Healthcare Data Science at Nanjing University, School of Life Sciences, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China.
Lingkai KongState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China; Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250021, China; "Nanjing University-Gulou" Joint Laboratory of AI and Healthcare BigData, National Institute of Healthcare Data Science at Nanjing University, School of Life Sciences, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China.
Yuxin ZhangState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China; Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250021, China; "Nanjing University-Gulou" Joint Laboratory of AI and Healthcare BigData, National Institute of Healthcare Data Science at Nanjing University, School of Life Sciences, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China.
Xiaosong GuState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China; Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250021, China. Electronic address: nervegu@ntu.edu.cn.
Chunping JiangState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China; Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250021, China; "Nanjing University-Gulou" Joint Laboratory of AI and Healthcare BigData, National Institute of Healthcare Data Science at Nanjing University, School of Life Sciences, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China; Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Fujian Medical University, 362000 Quanzhou, Fujian Province, China; Renhuai People's Hospital, 564055 Renhuai, Guizhou Province, China. Electronic address: chunpingjiang@nju.edu.cn.
Junhua WuState Key Laboratory of Pharmaceutical Biotechnology, Department of General Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210008, China; Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250021, China; "Nanjing University-Gulou" Joint Laboratory of AI and Healthcare BigData, National Institute of Healthcare Data Science at Nanjing University, School of Life Sciences, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China. Electronic address: wujunhua@nju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTumor-associated macrophages (TAMs) depend on their amino acid metabolism to determine their properties and immune function and play important roles in the tumor microenvironment (TME). Although in previous studies, targeting amino acid metabolism to transform the protumor function of TAMs into antitumor immune function has shown promising application as a tumor therapy, current clinical research is still limited. There is a lack of discussion on the mechanism and treatment strategy for determining tumor progression by controlling amino acid metabolism in TAMs, as does a summary of studies on promoting tumor progression by reshaping amino acid metabolism in TAMs. AIM OF REVIEW: This review aims to systematically review and summarize the crosstalk between amino acid metabolism in TAMs and the TME, analyze the determining role of its metabolic network in tumor occurrence and development, and summarize therapies on this basis to help determine the development status and emerging technologies in the field of amino acid metabolism in TAMs for tumor therapy. KEY SCIENTIFIC CONCEPTS OF REVIEW: This review dissects how TAMs exploit amino acid dynamics via transporters, enzymes, and sensors to adopt protumoral phenotypes, depleting critical metabolites and crippling antitumor T-cell responses. We map the immunometabolic crosstalk through which TAMs reshape immunity, highlighting nutrient competition and metabolic byproducts as dual drivers of immune dysfunction. Emerging therapeutic strategies targeting these pathways (IFN-γ-JAK-STAT1 and IL-6/JAK2/STAT3) have been critically evaluated for their potential to reprogram TAMs and reverse immunosuppression. Key challenges, such as TAM heterogeneity, metabolic plasticity, and therapy resistance, are addressed, emphasizing the need for single-cell-resolution mapping of TAM metabolic states to identify context-dependent vulnerabilities. Finally, we advocate for combinatorial approaches that couple metabolic rewiring with immunotherapies, proposing that disrupting amino acid dependencies in TAMs could dismantle the immunosuppressive TME.

Indexed as

Amino AcidsNeoplasmsTumor-Associated MacrophagesTumor MicroenvironmentAnimalsHumansMetabolic ReprogrammingAmino AcidsAmino acidImmunometabolic crosstalkImmunotherapyM1-like TAMsM2-like TAMsMetabolic crosstalkMetabolic reprogrammingTherapeutic targetTumor-associated macrophages (TAMs)Tumor microenvironment (TME)

Identifiers

PMID40975127
PMCPMC13227279

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.