Evidence map›Paper›PMID 40975299›Full record

Trial reportJournal of neuroscience methods2025

Wireless high-density electroencephalography in the perioperative setting.

Nathan Runstadler, Selena Martinez, UnCheol Lee, Duan Li, Kourosh Maboudi, George A Mashour, Phillip E Vlisides

Registry-linked trialAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neuroscience methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05574400 (The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05574400 phase2completednot on this map

The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study

TypeinterventionalSponsorUniversity of MichiganRan2023 to 2026Enrolled250ConditionsPostoperative Delirium, Postoperative Cognitive Dysfunction, Mild Cognitive ImpairmentArmsDextrose Water, Caffeine citrate
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nathan RunstadlerDepartment of Anesthesiology, Michigan Medicine, Ann Arbor, MI, USA.
Selena MartinezDepartment of Anesthesiology, Michigan Medicine, Ann Arbor, MI, USA.
UnCheol LeeDepartment of Anesthesiology, Michigan Medicine, Ann Arbor, MI, USA; Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, USA.
Duan LiDepartment of Anesthesiology, Michigan Medicine, Ann Arbor, MI, USA; Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, USA.
Kourosh MaboudiDepartment of Anesthesiology, Michigan Medicine, Ann Arbor, MI, USA.
George A MashourDepartment of Anesthesiology, Michigan Medicine, Ann Arbor, MI, USA; Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA.
Phillip E VlisidesDepartment of Anesthesiology, Michigan Medicine, Ann Arbor, MI, USA; Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: pvliside@med.umich.edu.

Funding

Caffeine and Postoperative Neurocognitive RecoveryR01AG075005 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Phillip Eleas Vlisides · 2022 to 2026
$2.7M
NIA NIH HHS R01 AG075005
6 · The paper itself

Abstract

backgroundElectroencephalographic (EEG) systems used in the operating room are constrained to frontal channels, providing limited neuroanatomical insights into altered perioperative brain states. Our objective is to present pragmatic strategies for placing whole-scalp, high-density EEG systems perioperatively that enable more comprehensive analysis. NEW

methodWe present the successful implementation of wireless high-density (72-channel) EEG in the perioperative setting for the ongoing Caffeine, Postoperative Delirium, and Change in Outcomes after Surgery (CAPACHINOS-2) clinical trial (NCT05574400). Placement time was calculated, impedance and data quality were assessed, and data acquisition and analysis pipelines were established. Lastly, proof-of-principle analyses using source localization were conducted.

resultsHigh-density wireless EEG data have been successfully acquired for n = 45 participants, with median (interquartile range) placement time of 34 (25 - 52) minutes. Data acquisition was supported by an established workflow, and a subsequent data processing pipeline was used to evaluate channel quality, remove artifacts, and generate proof-of-principle high-density analyses. COMPARISON WITH EXISTING

methodsCompared to a low-density system used for a similar, previous clinical trial (n = 54 participants), preoperative median impedance values (kΩ) were lower with the high-density system (13 [11-16] vs. 39 [28-47] kΩ; p < 0.001). Additionally, proof-of-principle analysis demonstrates a more complex connectivity matrix and broader distribution of cortical alpha rhythms after induction of general anesthesia with the high-density system, highlighting an expanded capacity for neurophysiologic analysis.

conclusionsWireless high-density EEG serves as a feasible, promising tool to advance understanding of altered perioperative brain states by providing high spatiotemporal resolution of cortical oscillations.

Indexed as

BrainElectroencephalographyIntraoperative Neurophysiological MonitoringWireless TechnologyAdultCaffeineFemaleHumansMaleMiddle AgedCaffeineElectroencephalographyNeuroanesthesiaNeurophysiological monitoringPerioperative periodWireless technology

Identifiers

PMID40975299
PMCPMC12481166

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.