Evidence map›Paper›PMID 40975371›Full record

Observational studyOsteoarthritis and cartilage2025

Entheseal bone remodeling and patient reported outcomes in osteoarthritis - A quantitative [18F]NaF-PET MRI study.

Katharina Ziegeler, Virginie Kreutzinger, Lianne S Gensler, Rupsa Bhattacharjee, Misung Han, Eric Hammond, Laura Chen, Emma Bahroos, Zehra Akkaya, Thomas M Link and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Osteoarthritis and cartilage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Katharina ZiegelerDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. Electronic address: Katharina.ziegeler17@gmail.com.
Virginie KreutzingerDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. Electronic address: Virginie.kreutzinger@ucsf.edu.
Lianne S GenslerDepartment of Medicine, Division of Rheumatology, University of California, San Francisco, CA, USA. Electronic address: lianne.gensler@ucsf.edu.
Rupsa BhattacharjeeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. Electronic address: rupsa.bhattacharjee@ucsf.edu.
Misung HanDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. Electronic address: misung.han@ucsf.edu.
Eric HammondDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA. Electronic address: eric.hammond@ucsf.edu.
Laura ChenDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. Electronic address: laura.chen@ucsf.edu.
Emma BahroosDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. Electronic address: emma.bahroos@ucsf.edu.
Zehra AkkayaDepartment of Radiology, Ankara University, Ankara, Turkey. Electronic address: zehraakkaya@gmail.com.
Thomas M LinkDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA. Electronic address: Thomas.link@ucsf.edu.
Richard B SouzaDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA. Electronic address: Richard.souza@ucsf.edu.
Sharmila MajumdarDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. Electronic address: sharmila.majumdar@ucsf.edu.

Funding

Simultaneous Imaging of Tissue Biochemistry and Metabolism associated with Biomechanics in Patella Femoral Joint OsteoarthritisR01AR079647 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sharmila Majumdar, Richard Brian Souza · 2022 to 2026
$3.4M
Mentoring Biomechanics Research in OsteoarthritisK24AR072133 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Richard Brian Souza · 2018 to 2026
$1.5M
NIAMS NIH HHS K24 AR072133NIAMS NIH HHS R01 AR079647
6 · The paper itself

Abstract

objectiveEntheses have been discussed as potential sources of pain in osteoarthritis (OA). Entheseal bone remodeling quantified by [18F]NaF-PET could be a surrogate marker for tensile forces causing a painful tissue response. This study aimed to investigate the relationship between [18 F]NaF-uptake, MRI findings and knee-related symptoms.

methodPatients and healthy controls in this prospective observational study on patello-femoral OA (PFJOA) underwent simultaneous MR (at 3.0 T) and [18F]NaF PET imaging of both knees. Cartilage damage, subchondral marrow lesions, synovitis, and enthesophytes were semi-quantitatively assessed on MRI and entheseal tracer uptake was quantified in the anterior patella and tibial tuberosity. Symptoms were assessed with the Knee injury and Osteoarthritis Outcome Score (KOOS). Generalized estimating equations were used to investigate associations between tracer uptake and symptoms; analyses were additionally adjusted for MRI-detected changes (as alternative symptom drivers), age, sex and body mass index.

resultsA total of 135 knees from 68 subjects were investigated (mean age 48.8 ± 10.4 years; 58.8% women). Higher [18F]NaF-uptake was significantly associated with worse outcomes for KOOS subscales sports (beta -2.7; p<0.001), quality of live (beta 3.0; p<0.001) and PFJ (beta 2.3; p=0.001), but not pain (beta -0.8; p=0.18), symptoms (beta -0.6; p=0.30) or activities of daily living (beta -1.1; p=0.06).

conclusionEntheseal bone remodeling quantified by [18F]NaF-PET-MRI is associated with patient-reported clinical knee outcomes. These findings underscore the potential of entheseal biology to inform the understanding of symptom generation in degenerative disease of the musculoskeletal system.

Indexed as

Bone RemodelingOsteoarthritis, KneeAdultCase-Control StudiesFemaleFluorine RadioisotopesHumansMagnetic Resonance ImagingMaleMiddle AgedPatellofemoral JointPatient Reported Outcome MeasuresPositron-Emission TomographyProspective StudiesRadiopharmaceuticalsSodium FluorideFluorine RadioisotopesRadiopharmaceuticalsSodium FluorideBone remodelingEnthesesMagnetic resonance imagingPainPET imagingPFJ-OA

Identifiers

PMID40975371
PMCPMC12969754

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.