Chronic administration of the hydrogen sulfide prodrug SG1002 partially protects against erectile dysfunction resulting from long-term androgen deprivation.

Colin M Ihrig, Clifford J Pierre, Tooyib A Azeez, Justin D La Favor

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Article in Life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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Chronic administration of the hydrogen sulfide prodrug SG1002 partially protects against erectile dysfunction resulting from long-term androgen deprivation.2025

5 · Who and what money

Authors and funding

4 authors.

Colin M IhrigDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA.

Clifford J PierreDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA.

Tooyib A AzeezDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA.

Justin D La FavorDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA. Electronic address: jlafavor@fsu.edu.

Funding

Role of Testosterone Induction of Hydrogen Sulfide in Erectile DysfunctionR03DK131242 · NIDDK · FLORIDA STATE UNIVERSITY · PI Justin David LaFavor · 2023 to 2023

$109k

NIDDK NIH HHS K01 DK115540NIDDK NIH HHS R03 DK131242

6 · The paper itself

Abstract

aimsAndrogen deprivation therapy is a common treatment strategy for prostate cancer, although erectile dysfunction (ED) often coincides as an undesirable side-effect. Hydrogen sulfide (H MATERIALS AND

methods14-week-old male C57Bl/6 mice were subjected to sham surgery or castration, with castrated mice remaining untreated or treated orally with low- or high-doses of the H KEY

findingsSG1002 provided a moderate protection on erectile function against long-term androgen deprivation. Castration-induced alterations of several mechanisms of vasodilation and vasoconstriction of the CC and IPA were substantial, while alterations of the IIA modest, with subtle effects of SG1002 treatment across the vascular beds. SG1002 partially protected against castration-induced fibrotic remodeling of the IPA. SIGNIFICANCE: H

Indexed as

Androgen AntagonistsErectile DysfunctionHydrogen SulfideProdrugsAnimalsMaleMiceMice, Inbred C57BLPenile ErectionPenisAndrogen AntagonistsHydrogen SulfideProdrugsCastrationHypogonadismIliac arteryMyographPudendal arteryTestosterone

Identifiers

PMID40975375

DOI10.1016/j.lfs.2025.123976

PMCPMC12952273

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LicenceCC BY-NC

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